Assessment of Seroconversion to SARS-CoV-2 in a Cohort of Pediatric Kidney Transplant Recipients.

Frontiers in Pediatrics
Corina NailescuDavid S Hains

Abstract

Background: The occurrence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated coronavirus disease 2019 (COVID-19) have profoundly affected adult kidney disease patients. In contrast, pediatric solid organ transplant recipients, including pediatric kidney transplant (KT) recipients, do not seem to be at particularly higher risk for SARS-CoV-2 infection or for severe COVID-19 disease. This patient population might be protected by certain mechanisms, such as the immunosuppressive medications with their anti-inflammatory properties or simply being well-versed in self-protection techniques. Assessing SARS-CoV-2 antibody serologies could potentially help understand why this patient population is apparently spared from severe SARS-CoV-2 clinical courses. Objective: To examine SARS-CoV-2 serologic status in a cohort of pediatric KT recipients. Methods: SARS-CoV-2 anti-spike IgG and IgM antibodies were measured by three different methods in pediatric KT recipients coming for routine clinic visits immediately post-confinement in May-June of 2020. The patients were considered seroconverted if SARS-CoV-2 antibodies were positive by 2/3 methods and weak positive/indeterminate if positive by 1/3. Results: ...Continue Reading

References

Oct 1, 1990·Epidemiology and Infection·K A CallowD A Tyrrell
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chris Ka-fai LiXiao-Ning Xu
Dec 25, 2015·Proceedings. Biological Sciences·A Katharina SimonAndrew McMichael
Dec 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sema NickbakhshPablo R Murcia
Mar 10, 2020·JAMA : the Journal of the American Medical Association·Joshua M SharfsteinMichelle M Mello
Mar 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Li GuoJianwei Wang
Mar 23, 2020·The Lancet Infectious Diseases·Yang LiuWei Zhang
Apr 9, 2020·Emerging Infectious Diseases·Nisreen M A OkbaBart L Haagmans
Apr 18, 2020·Current Protocols in Microbiology·Daniel StadlbauerFlorian Krammer
Apr 25, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Marcus R PereiraElizabeth C Verna
May 12, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nisha S MehtaJonathan S Nguyen-Van-Tam
May 14, 2020·Nature Medicine·Fatima AmanatFlorian Krammer
May 15, 2020·JAMA : the Journal of the American Medical Association·David S HainsFlorian Krammer
May 16, 2020·The Lancet Child & Adolescent Health·Matko MarlaisKjell Tullus
May 21, 2020·JAMA : the Journal of the American Medical Association·Supinda BunyavanichAlfin Vicencio
Jun 2, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Monica FungJennifer M Babik
Jun 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Monica Fung, Jennifer M Babik
Jul 1, 2020·MedRxiv : the Preprint Server for Health Sciences·Jennifer HicksKaitlyn Sadtler
Jul 24, 2020·MMWR. Morbidity and Mortality Weekly Report·Nir MenachemiPaul K Halverson
Jan 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Monica Fung, Jennifer M Babik

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Citations

Mar 11, 2021·Pediatric Transplantation·Arnaud G L'HuillierMonica I Ardura
Apr 9, 2021·BMC Nephrology·Alanoud AlshamiNorah Al-Quhaidan
Sep 2, 2021·European Journal of Pediatrics·Benedikt BötticherGisela Janßen

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
Assay
ELISA
ELISAs
PCR

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