Assessment of serum proteomics to detect large colon adenomas.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
David F RansohoffRobert S Sandler

Abstract

A noninvasive blood test that could reliably detect early colorectal cancer or large adenomas would provide an important advance in colon cancer screening. The purpose of this study was to determine whether a serum proteomics assay could discriminate between persons with and without a large (> or =1 cm) colon adenoma. To avoid problems of "bias" that have affected many studies about molecular markers for diagnosis, specimens were obtained from a previously conducted study of colorectal cancer etiology in which bloods had been collected before the presence or absence of neoplasm had been determined by colonoscopy, helping to assure that biases related to differences in sample collection and handling would be avoided. Mass spectra of 65 unblinded serum samples were acquired using a nanoelectrospray ionization source on a QSTAR-XL mass spectrometer. Classification patterns were developed using the ProteomeQuest algorithm, performing measurements twice on each specimen, and then applied to a blinded validation set of 70 specimens. After removing 33 specimens that had discordant results, the "test group" comprised 37 specimens that had never been used in training. Although in the primary analysis, no discrimination was found, a sing...Continue Reading

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Citations

Dec 24, 2008·Digestive Diseases and Sciences·Ying LinRobert R Schade
Jun 28, 2012·Revista da Associação Médica Brasileira·Eduardo Buzolin BarbosaEloiza Helena Tajara
Dec 30, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David F Ransohoff, Margaret L Gourlay
Mar 21, 2009·Expert Review of Molecular Diagnostics·Kjetil SøreideHartwig Kørner
May 26, 2011·Clinical Colorectal Cancer·Linda J W BoschGerrit A Meijer
May 14, 2009·Rapid Communications in Mass Spectrometry : RCM·Paolo LecchiJohn M Peltier
Sep 1, 2011·Mass Spectrometry Reviews·Peihong ZhuJohn G Marshall
Jul 1, 2014·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Ao KongRobert Azencott
Oct 9, 2008·Journal of the National Cancer Institute·David F Ransohoff

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