Assessment of spiramycin-loaded chitosan nanoparticles treatment on acute and chronic toxoplasmosis in mice

Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology
Samia E EtewaMahmoud A El-Shafey

Abstract

Toxoplasmosis is a zoonotic parasitic disease with worldwide distribution. Chitosan is a natural polymer which is commonly used in the production of nanomedicines. It is known to enable higher drug permeation, being biocompatible and has very low toxicity, besides its antimicrobial effects. Our study aimed to assess the effect of spiramycin-loaded chitosan nanoparticles (SLCNs) in treatment of acute and chronic toxoplasmosis in mice. 200 male Swiss albino mice were included in our study, divided to two main groups; Toxoplasma gondii RH strain infected group and ME49 strain infected group, each main group was subdivided into four subgroups; subgroup I: infected control, subgroup II: infected and received chitosan nanoparticles (CS NPs); 20 µg of CS NPs in 100 µl of PBS/mouse/dose, subgroup III: infected and treated with spiramycin (Rovamycin); 100 mg/kg/day, subgroup IV: infected and treated with 100 mg/kg/day spiramycin-loaded chitosan nanoparticles. Effect of treatment was assessed parasitologically and histopathologically. It was noticed that SLCNs significantly decreased the mortality rate of infected mice with both strains compared to high mortality rate of mice in the infected control subgroups. Moreover, there was a signi...Continue Reading

References

Nov 1, 1992·Antimicrobial Agents and Chemotherapy·F G AraujoJ S Remington
Apr 1, 1991·Antimicrobial Agents and Chemotherapy·G A Filice, C Pomeroy
Aug 1, 1986·Antimicrobial Agents and Chemotherapy·J Chan, B J Luft
Jul 1, 1985·The Journal of Antimicrobial Chemotherapy·S Kernbaum
Oct 1, 1994·Memórias do Instituto Oswaldo Cruz·M L PenidoP M Coelho
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J C BoothroydS Tomavo
Mar 28, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·P Mourier, A Brun
Dec 16, 1998·The Journal of Antimicrobial Chemotherapy·E Rubinstein, N Keller
Apr 18, 2000·International Journal of Pharmaceutics·G L EngelL L Winneroski
May 2, 2000·Drug Development and Industrial Pharmacy·A FarinhaP Tavares
Dec 19, 2000·Infection and Immunity·Y W ZhangL M Weiss
Mar 17, 2001·Advanced Drug Delivery Reviews·K A JanesM J Alonso
May 4, 2004·Journal of Nanobiotechnology·OV Salata
May 8, 2004·International Journal of Pharmaceutics·Anant ParadkarK R Mahadik
Dec 1, 2006·Annals of the New York Academy of Sciences·Anyarat ThiptaraSomsak Anan
Aug 29, 2007·International Journal of Nanomedicine·Katherine Bowman, Kam W Leong
Dec 14, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elsa BrionesJosé M Lanao
Jul 16, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jose G Montoya, Jack S Remington
May 12, 2009·Memórias do Instituto Oswaldo Cruz·Erik JongertEskild Petersen
Oct 6, 2009·Advanced Drug Delivery Reviews·T Kean, M Thanou
Mar 11, 2010·Methods in Molecular Biology·Juliana M ChanOmid C Farokhzad
Nov 26, 2010·Current Drug Discovery Technologies·Fernanda AndradeBruno Sarmento
May 24, 2011·Expert Opinion on Drug Delivery·José das NevesBruno Sarmento
May 19, 2012·Experimental Parasitology·Maha M EissaNahed M Baddour
Sep 27, 2012·Colloids and Surfaces. B, Biointerfaces·Shuting JiangGuoming Xie
Mar 16, 2013·Current Pharmaceutical Design·Najeh Maissar KhalilRubiana Mara Mainardes
May 24, 2014·Experimental Parasitology·M R GaafarTh I Shalaby
Dec 17, 2014·Experimental Parasitology·Lobna A El-ZawawySalwa S Younis
Oct 9, 2015·Parasitology Research·Rasha F MadySamar Elachy
Sep 9, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Mona M El TemsahyNermine M F H Mogahed

❮ Previous
Next ❯

Citations

Nov 21, 2019·Drug Delivery·Yuzhu SunShuyu Xie
Jun 13, 2019·Parasitology Research·Shahira A AhmedPanagiotis Karanis
Oct 16, 2019·Current Pharmaceutical Design·Brenna Louise Cavalcanti GondimMarcos Vinicius da Silva
Feb 26, 2020·Food and Waterborne Parasitology·Neda KonstantinovicFlorence Robert-Gangneux
Dec 22, 2020·International Journal for Parasitology·Nicholas C SmithGiel G van Dooren
Feb 11, 2021·World Journal of Microbiology & Biotechnology·Sanaz Jafarpour AzamiMohammad Reza Zali
Sep 4, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Howayda Said Fouad MoawadAmira Abd El-Lateef Saleh Ali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic]
S V Budanov
Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology
Nagwa Mostafa El-SayedKhaled Fathy Elhasanein
Nederlands tijdschrift voor geneeskunde
P MASBAKAL INTVELD
© 2022 Meta ULC. All rights reserved