Assessment of statin therapy, LDL-C levels, and cardiovascular events among high-risk patients in the United States

Journal of Clinical Lipidology
Sudhir K UnniShravanthi R Gandra

Abstract

Statins have demonstrated significant benefit in reducing cardiovascular disease (CVD) risk. To evaluate statin treatment patterns by intensity, elevated low-density lipoprotein cholesterol (LDL-C) levels, and cardiovascular (CV) events in high-risk CVD patients. Patients included were aged ≥ 18 years, with a coronary heart disease (CHD; Jan 1, 2007-Dec 31, 2011, index date) or CHD risk equivalent (CHD RE) diagnosis (Jan 1, 2007-Dec 31, 2010, index date), in the Truven MarketScan claims database, continuously enrolled for 2 years pre- and up to 1 (CHD) or 2 (CHD RE) years post-index. Patients with CHD, CHD RE, rhabdomyolysis, or chronic kidney disease any time pre-index were excluded. Statin therapy was assessed at baseline, 30, 90, and 365 days post-index. LDL-C values were captured in patients with available data at 30-day intervals up to 1 year. CV events were evaluated up to 1 year post-index. Descriptive statistics were used to report results. There were 175,103 CHD and 68,290 CHD RE patients; 3333 CHD RE patients had post-index CV events. At 1 year, 38.7% of CHD patients and 44.3% of CHD RE patients with post-index CV events were not prescribed statins. Most patients who were prescribed statins, received a moderate-intens...Continue Reading

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Citations

Apr 11, 2017·Journal of the American Association of Nurse Practitioners·Nicole Ciffone, Betsy B Dokken
Feb 14, 2017·Journal of Translational Internal Medicine·Bennur EsenAhmet Engin Atay
May 26, 2021·Scientific Reports·Malihe AghasizadehToba Kazemi

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