Assessment of steady-state clopidogrel reactivity by using platelet reactivity units

American Journal of Therapeutics
Seemab RasoolMohammad M AlOrainy

Abstract

Platelet function testing is an important laboratory measure in clopidogrel treatment. We sought to investigate the stability of the reactivity of clopidogrel after 1 month of treatment. A prospective analysis was carried out using a matched study design to compare platelet reactivity units (PRUs) and platelet inhibition in clopidogrel-treated patients. Patients with various cardiac diseases were divided into 2 matched groups. The first group was treated on an inpatient acute basis, and the other group was treated on an outpatient chronic basis. PRU was measured 5 days after clopidogrel administration in the acute group and 1 month after chronic use for several cardiac indications in the second group. VerifyNow (Accumetrics) was used to detect platelet reactivity and calculate inhibition rates in response to clopidogrel. A total of 260 Saudi patients were enrolled, including 90 inpatients and 170 outpatients. A significant difference was observed in PRU (173.69 vs. 195) and percent inhibition (24.05% vs. 16.13%) between the outpatient and inpatient groups. Platelet function evolves over time and initial readings may not be constant.

References

Jul 18, 2006·Methods and Findings in Experimental and Clinical Pharmacology·A MalininV Serebruany
Sep 18, 2007·Journal of the American College of Cardiology·Gianluca CampoRoberto Ferrari
Feb 17, 2010·Journal of Thrombosis and Thrombolysis·Gianluca CampoRoberto Ferrari
Sep 27, 2013·European Heart Journal·Dániel AradiUNKNOWN Working Group on Thrombosis of the European Society of Cardiology

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