Assessment of Subclinical Pancreatitis in Epileptic Children With Different Treatment Modalities

Child Neurology Open
Doa Mohamed MahrousAliaa Monir Higazi

Abstract

Acute pancreatitis differ in pediatrics and adults. Drug-induced pancreatitis is one of the common causes of pancreatitis in children. This case-control study aimed to assess subclinical pancreatitis in patients with epilepsy treated with different drug regimens. Eighty known patients with epilepsy were enrolled. Forty patients were treated with monotherapy (group I) and 40 were treated with multitherapy (group II) regimens. Twenty age- and sex-matched healthy children were enrolled as control (group III). Serum lipase and amylase were assayed in all included children. Significant differences were found between groups I and III and between groups II and III regarding serum amylase and lipase (P < .001 for all). Significant difference were found between groups I and II (P = .024) and between groups II and III (P = .01) regarding pancreatic duct and body diameters. Significant difference were found between patients with controlled and uncontrolled fits regarding serum amylase (P = .008). In conclusion, subclinical pancreatitis can complicate the treatment with different antiepileptic regimens.

References

May 15, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Rodriguez-SegadeR Del Río
Jan 1, 1993·Annales de chirurgie·E L Bradley
Nov 7, 2000·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·H C ChaoC C Luo
Jan 24, 2002·Therapeutic Drug Monitoring·Emilio Perucca
Nov 9, 2002·Epilepsia·John M PellockKenneth W Sommerville
Nov 6, 2004·Journal of Child Neurology·D Barry SinclairRene Breault
Dec 16, 2004·Journal of Pharmacological Sciences·Sherifa A HamedNagla El-Melegy
Jun 30, 2005·The Journal of Clinical Psychiatry·Francisco A MorenoBrian Schreiber
Apr 29, 2006·American Journal of Therapeutics·Mette NørgaardHenrik Toft Sørensen
Mar 31, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nison BadalovScott Tenner
Dec 25, 2007·The Journal of Pediatrics·Leena Kandula, Mark E Lowe
Jun 9, 2009·Journal of Pediatric Gastroenterology and Nutrition·Alexander ParkSohail Zakiuddin Husain
Jul 23, 2009·Arquivos de neuro-psiquiatria·José Guevara-CamposJuan Manuel Rojas
Jun 18, 2011·Journal of Pediatric Gastroenterology and Nutrition·Harrison X BaiSohail Z Husain

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

SPSS Statistical Package for Social Sciences )

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