Assessment of the ability of open- and closed-loop cueing to improve turning and freezing in people with Parkinson's disease

Scientific Reports
Martina ManciniJohn G Nutt

Abstract

Turning impairments are common in Parkinson's disease (PD) and can elicit freezing of gait (FoG). Extensive examination of open-loop cueing interventions has demonstrated that they can ameliorate gait deficits in PD; less is known about efficacy to improve turning. Here, we investigate the immediate effectiveness of open- and closed-loop cueing in improving turning characteristics in people with PD. Twenty-five subjects with and 18 subjects without FoG participated in the study. Subjects turned in place for one minute under single- and dual-task for 3 randomized conditions: (i) Baseline; (ii) Turning to the beat of a metronome (open-loop); and (iii) Turning with phase-dependent tactile biofeedback (closed-loop). Objective measures of freezing, such as % time spent freezing and FoG-ratio, significantly improved when turning with both open-loop and closed-loop cueing compared to baseline. Dual-tasking did not worsen FoG in freezers, but significantly slowed down turns in both groups. Both cueing modalities significantly improved turning smoothness in both groups, but reduced turning velocity and number of turns compared to baseline. Both open and closed-loop cueing markedly improved turning in people with PD. These preliminary ob...Continue Reading

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Dec 14, 2016·Neuroscience·Martina ManciniJohn G Nutt

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Citations

Aug 17, 2019·Expert Review of Neurotherapeutics·Martijn L T M MüllerNicolaas I Bohnen
Sep 29, 2019·Journal of Parkinson's Disease·Daniel S PetersonKatrijn Smulders
Dec 24, 2019·Journal of Parkinson's Disease·Urban M FietzekAndres O Ceballos-Baumann
Aug 20, 2019·Journal of Neurologic Physical Therapy : JNPT·Samuel Stuart, Martina Mancini
Oct 15, 2019·Frontiers in Aging Neuroscience·Mattia CorzaniLorenzo Chiari
Dec 15, 2019·Sensors·Niveditha MuthukrishnanNarayanan Krishnamurthi
Jan 6, 2021·Journal of Neuroengineering and Rehabilitation·Martina ManciniJohn G Nutt
Nov 14, 2020·Sensors·Niveditha MuthukrishnanNarayanan Krishnamurthi
May 11, 2021·Medical & Biological Engineering & Computing·Helena R GonçalvesCristina P Santos

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VibroGait
MATLAB
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