Assessment of the anti-hyperalgesic efficacy of J-2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP).

Clinical and Experimental Pharmacology & Physiology
Andy KuoMaree T Smith

Abstract

Chronic mechanical low back pain (cLBP) is a leading cause of disability and a major socio-economic burden internationally. The lifetime prevalence of non-specific LBP is approximately 84%, with the prevalence of cLBP at about 23%. Clinically available analgesic/adjuvant medications often provide inadequate pain relief in patients experiencing cLBP. Hence, the urgency for discovery of effective and better tolerated medications. Fourteen days after the induction of five shallow annular punctures (5X) in the lumbar intervertebral discs at L4/L5 and L5/L6 in male Sprague-Dawley rats, mechanical hyperalgesia was fully developed in the lumbar axial deep tissues at L4/L5 (primary) and L1 (secondary). Importantly, mechanical allodynia in the hindpaws was absent. From day 28, we assessed the face validity of our mild to moderate LBP-5X rat model using four clinically available analgesic/adjuvant drugs, namely gabapentin, morphine, meloxicam and amitriptyline relative to vehicle. Additionally, the anti-hyperalgesic effects of J-2156, a highly selective small molecule somatostatin type 4 receptor agonist was assessed. Single i.p. bolus doses of gabapentin and meloxicam at the highest doses tested (100 and 30 mg/kg, respectively) alleviat...Continue Reading

References

Jan 1, 1983·Current Medical Research and Opinion·D S Robinson
Nov 24, 1995·Science·A TaddeseE W McCleskey
Mar 1, 1996·Drugs·S Noble, J A Balfour
Dec 15, 1996·Spine·M Von Korff, K Saunders
May 16, 2006·European Journal of Pharmacology·Katalin SándorZsuzsanna Helyes
Jun 13, 2006·Pharmacology & Therapeutics·Erika PintérJános Szolcsányi
Dec 17, 2008·European Journal of Pain : EJP·Ashraf A DahabaHelfried Metzler
Aug 4, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·T KuijpersM W van Tulder
Jan 27, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael J DePalmaThomas Saullo
Jan 11, 2012·Arthritis and Rheumatism·Damian HoyRachelle Buchbinder
May 30, 2013·British Journal of Clinical Pharmacology·Nick Holford
Mar 26, 2014·Annals of the Rheumatic Diseases·Damian HoyRachelle Buchbinder
Jan 7, 2015·BMJ : British Medical Journal·Richard A DeyoDavid Duhrkoop
Dec 15, 2015·Mayo Clinic Proceedings·W Michael Hooten, Steven P Cohen
Mar 5, 2016·European Journal of Pain : EJP·R BaronR-D Treede
Oct 27, 2016·F1000Research·Massimo AllegriGuido Fanelli
Jul 5, 2018·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Oliver EnkeC-W Christine Lin
Jun 11, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Thomas S W ParkMaree T Smith

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.