Assessment of the chorioallantoic membrane vascular assay (CAMVA) in the COLIPA in vitro eye irritation validation study

Toxicology in Vitro : an International Journal Published in Association with BIBRA
D M BagleyJ W Harbell

Abstract

The chorioallantoic membrane vascular assay (CAMVA) is an alternative to the Draize rabbit eye irritation method. The CAMVA employs the vascularized membrane of a fertile hen's egg to assess eye irritation potential. This irritation potential is a function of alterations in the vasculature following the administration of test material. Because of the history of use of the CAMVA it was selected as one of the methods for a validation study organized and sponsored by COLIPA. For this validation study mathematical prediction models (PMs) were developed to convert the CAMVA results into predicted Draize eye irritation scores known as a modified maximum average Draize score (MMAS). These predicted scores were statistically compared with the observed scores to assess the relevance of the CAMVA. The assay was conducted on the same set of test materials by two independent laboratories. These two sets of data were compared to assess the interlaboratory reproducibility of the assay. The results of this validation study of the CAMVA show that for test materials with MMASs in the 0 to 5 range or the 55 to 110 range, the CAMVA did not give a good prediction. The predictions were better for samples of mild to moderate irritation (MMAS 5-55). ...Continue Reading

References

Dec 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D M BagleyB M Kong
Oct 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S D GettingsR Gay
Jan 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H SpielmannW Steiling
Feb 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P G BrantomM Stern
Jul 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D M BagleyA P Walker

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Citations

Jan 13, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M P Vinardell, M Mitjans
Apr 28, 2009·Regulatory Toxicology and Pharmacology : RTP·Pauline McNameeJulia Scheel
Oct 1, 2005·Alternatives to Laboratory Animals : ATLA·Chantra EskesValérie Zuang
Jan 7, 2003·Alternatives to Laboratory Animals : ATLA·Rodger D Curren, John W Harbell
Apr 10, 2010·Alternatives to Laboratory Animals : ATLA·Arnhild SchrageRobert Landsiedel
Dec 15, 2004·Alternatives to Laboratory Animals : ATLA·Ludwig A Hothorn
Oct 15, 2020·Journal of Cosmetic Dermatology·Xiao MaBo Wang

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