Assessment of the clinical efficacy of a hyaluronic acid-based deep wrinkle filler using new instrumental methods

Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology
V TurlierAnne-Marie Schmitt

Abstract

The efficacy of numerous hyaluronic acid (HA)-based fillers has been demonstrated by semi-quantitative and qualitative methods, useful in clinical practice, but poorly reliable. To objectively evaluate the efficacy of a HA gel in treating nasolabial folds (NLFs) over a 9-12-month follow-up period. A total of 47 adult patients with moderate to severe NLFs received one or two injections of HA gel. Efficacy was assessed by measuring NLF depth at time intervals up to 12 months subjectively by blind and open clinical scoring using the Lemperle scale, and objectively using skin replicas and in vivo 3D imaging methods. Tissue characterization and dermal thickness were also assessed using radiofrequency ultrasonography and high-resolution ultrasound imaging, respectively. The filler injection highly significantly decreased the depth of NLFs (p < 0.0001) at all time points, with an improvement of at least 1 grade in the Lemperle score in 77% and 89% of the subjects at 9 and 12 months, respectively. NLF volume measured on replicas and 3D images significantly decreased after injection and this improvement was maintained over 12 months. This HA gel is well tolerated and provides a significant and long-lasting correction of moderate to seve...Continue Reading

References

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Citations

Sep 18, 2012·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Kukizo MiyamotoAkira Kawada
Jun 9, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Patrick TrevidicCatherine Salomon
Jul 29, 2016·Plastic and Reconstructive Surgery·Daniel CassutoGiorgio De Santis
Aug 29, 2019·Journal of Cosmetic Dermatology·Leonie W SchelkeXimena Wortsman
Jan 12, 2021·Plastic and Reconstructive Surgery. Global Open·Patrick TrevidicFerial Fanian
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anca Maria JuncanFelicia Loghin

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