Abstract
Adenosine analogs such as 2-chloroadenosine are potent cerebrovasodilators. Spin-labeled MRI was used to investigate the spatial distribution, dose-response, and timing of the effect of 2-chloroadenosine on cerebral blood flow (CBF) after intraparenchymal injection into rat brain. Sprague-Dawley rats (N = 10) were injected with 2-chloroadenosine at doses of 0.3, 6.0, or 12 nmoles, or saline vehicle (2-4 microL). CBF was serially quantified in a slice through the injection site in a circular (3.6 mm diameter) region of interest (ROI) around the injection and in ipsilateral hemispheric ROIs at approximately 90 min and approximately 180 min. Marked 3.77- and 3.93-fold increases in CBF (vs. vehicle) were seen in the circular ROI at approximately 90 min and approximately 180 min after 12-nmol injection, respectively. Similarly, 2.92- and 2.78-fold increases in hemispheric CBF were observed at approximately 90 min and approximately 180 min, respectively, after injection of 12 nmoles. Linear dose-response relationships were observed at both times after injection in both ROIs (all P < 0.01). Spin-labeling MRI assessment revealed that parenchymal injection of 2-chloroadenosine produces potent, dose-dependent, and sustained vasodilation ...Continue Reading
References
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D S WilliamsA P Koretsky
Jan 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J A DetreA P Koretsky
Aug 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D G Van WylenR M Berne
Aug 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R N Kalaria, S I Harik
Dec 29, 1987·Neuroscience Letters·M C EvansB S Meldrum
May 11, 1981·Life Sciences·J W DalyS H Snyder
Sep 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E DóraA G Kovách
Feb 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A C SilvaA P Koretsky
Mar 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W ZhangA P Koretsky
Apr 1, 1995·Anesthesia and Analgesia·R M BryanC Robertson
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P HeadrickR Vink
Mar 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W ZhangA P Koretsky
May 12, 1997·European Journal of Pharmacology·A S Abdul-GhaniH F Bradford
Aug 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M L ForbesC Ho
May 12, 1998·The Journal of Physiology·A M Coney, J M Marshall
Sep 30, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K S HendrichC Ho
Citations
Oct 13, 2001·NMR in Biomedicine
Apr 2, 2004·Topics in Magnetic Resonance Imaging : TMRI·Xavier GolayTchoyoson C C Lim
Jul 25, 2006·The British Journal of Radiology·E T PetersenX Golay
Jun 3, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick M KochanekChien Ho
Sep 25, 2002·Brain Research·Manu R VarmaPatrick M Kochanek
Jul 10, 2003·Critical Care Clinics·Hülya BayirRobert S B Clark
Feb 6, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Denis E BraginEdwin M Nemoto
Jul 17, 2019·Current Pharmaceutical Design·Hira ChoudhuryBapi Gorain
Feb 23, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Edwin K JacksonPatrick M Kochanek