Assessment of the effect of a biphasic ceramic on bone response in a rat calvarial defect model

Journal of Biomedical Materials Research. Part a
Hakan DeveliogluLaurent Dupoirieux

Abstract

Calcium phosphate ceramics are being extensively used for orthopedic, periodontal, and dental applications. This study aimed to assess the effect of a biphasic ceramic such as Ceraform on the osteogenesis in a rat calvarial defect model. 20 Wistar rats were enrolled in the study. Two symmetrical, circular, and 5-mm-wide full thickness defects were created in the parietal bones of each animal. The left defect was left empty as a control and the right defect was filled with the particular implant material. Animals were divided into two groups, and 10 animals were sacrificed at month 3 and the rest were sacrificed at month 6. The calvarial specimens were harvested for histological examinations. Defect area samples were stained with hematoxylin-eosin and Masson Thrichrom. A semiquantitative method was used to quantify the bone regeneration. The defects were mostly filled with fibrous connective tissue (3-6 months) in the control site. A loose, fibrovascular tissue was observed at the side of ceraform implantation at month 3. By 6 month, a dense collagenous tissue was observed at the same area. Multinuclear giant cells (MNGC) were detected around the implant bed at month 3 and month 6. No necrosis, tumorigenesis, or infection was ob...Continue Reading

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Citations

Feb 27, 2008·Journal of Materials Science. Materials in Medicine·Natalia Miño FariñaAntonio González Cantalapiedra
Nov 7, 2009·Tissue Engineering. Part B, Reviews·George F MuschlerJeffrey O Hollinger
Jun 18, 2010·The Journal of Oral Implantology·Hakan DeveliogluLevent Taner
Mar 21, 2012·Advanced Drug Delivery Reviews·Wei JiJohn A Jansen
Nov 23, 2006·Journal of Biomedical Materials Research. Part a·Hakan DeveliogluZeynep Deniz Sahin
Mar 20, 2018·The Journal of Craniofacial Surgery·Majid RezaeiMasih Rezaee
Sep 6, 2019·Journal of Periodontal & Implant Science·Seo-Eun OhSungtae Kim
Mar 21, 2019·Acta Cirúrgica Brasileira·Nihat LaçinMehmet Cudi Tuncer
Mar 17, 2009·Physics in Medicine and Biology·Joseph U UmohDavid W Holdsworth
Jun 6, 2019·The Journal of Craniofacial Surgery·Ozge DoganayBelir Atalay
Jan 9, 2015·The Journal of Craniofacial Surgery·Stephanie M PowerDavid W Holdsworth

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