PMID: 9546419Apr 18, 1998Paper

Assessment of the effect of the oral iron chelator deferiprone on asymptomatic Plasmodium falciparum parasitemia in humans

The American Journal of Tropical Medicine and Hygiene
P E ThumaVictor R Gordeuk

Abstract

While the parenteral iron-chelating agent desferrioxamine B has anti-malarial activity in humans, the usefulness of an orally active chelator for this indication has not been investigated previously in vivo. We conducted a prospective, double-blind, placebo-controlled, cross-over trial of deferiprone (L1; CP20; 1,2-dimethyl-3-hydroxypyridin-4-one) in 25 adult Zambians with asymptomatic Plasmodium falciparum parasitemia. Deferiprone was administered daily for three or four days in divided doses of 75 or 100 mg/kg of body weight, dosages that are effective for treating iron overload. No reduction in asexual intra-erythrocytic parasites was observed during or after deferiprone treatment. The mean peak plasma concentration of deferiprone (108.9 +/- 24.9 micromol/L) achieved was within the range demonstrated to inhibit the growth of P. falciparum in vitro, but the systemic exposure as determined by the 24-hr plasma concentration-time curve would not be predicted inhibit growth in vivo. No evidence of deferiprone-associated hematological toxicity was noted in this short-term study of these subjects, all of whom had clinical evidence of normal body iron stores. Because of the risk of neutropenia and other adverse effects with higher d...Continue Reading

Citations

Feb 15, 2002·British Journal of Haematology·C GoudeauH Nick
Jun 27, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·George J KontoghiorghesAnnita Kolnagou
Jun 14, 2003·The Cochrane Database of Systematic Reviews·H J Smith, M Meremikwu
Feb 27, 2008·Food and Nutrition Bulletin·Chaim Hershko
Sep 22, 2009·Drug Metabolism Reviews·Eugene D Weinberg, Jym Moon
Nov 15, 2011·EMBO Reports·Sílvia PortugalMaria M Mota
Oct 31, 2007·Multiple Sclerosis : Clinical and Laboratory Research·K M MitchellS M LeVine
Mar 2, 1999·Pharmacology & Therapeutics·G F MabezaG Weiss
Jan 25, 2008·Free Radical Biology & Medicine·Brandon J ReederMichael T Wilson

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