Assessment of the emetogenic potential of intrathecal chemotherapy and response to prophylactic treatment with ondansetron

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Mark T HoldsworthC M Chavez

Abstract

The purpose of this study was to document the emetogenic potential of intrathecal chemotherapy (IC) in children and to evaluate the efficacy of ondansetron in reducing nausea and vomiting with this chemotherapy treatment. Patients less than 18 years of age with acute lymphoblastic leukemia were eligible to participate in a survey project measuring the emetogenic potential of various chemotherapy treatments. Patients surveyed for 1 or more IC treatments were included in this report. The IC consisted of methotrexate, hydrocortisone and cytarabine, dosed according to patient age. A nausea/vomiting survey instrument was completed by each patient and/or parent following IC treatment. The instrument rated nausea, vomiting and daily activity interference (DAI) on a 4-point scale of 0 = none, 1 = mild, 2 = moderate and 3 = severe, and collected data on the number of vomiting and/or retching episodes in addition to the child's appetite following the chemotherapy treatment. When ondansetron was employed, it was administered in an i.v. infusion at a dose of 0.15 mg/kg before and after chemotherapy or as an oral dose of 4 mg or 8 mg before chemotherapy. Courses of IC without antiemetics were analyzed to determine the emetogenic potential o...Continue Reading

Citations

Oct 1, 2004·Expert Review of Pharmacoeconomics & Outcomes Research·Dennis RaischHeather Campbell
Sep 25, 2004·Pediatric Blood & Cancer·Emmanuel S AntonarakisRichard D W Hain
Jul 24, 2008·Pediatric Blood & Cancer·Kim NagelRonald D Barr
Apr 6, 2011·Pediatric Blood & Cancer·L Lee DupuisUNKNOWN Pediatric Oncology Group of Ontario
Mar 21, 2013·Pediatric Blood & Cancer·L Lee DupuisUNKNOWN Pediatric Oncology Group of Ontario
Jun 1, 2017·Pediatric Blood & Cancer·Melanie Brooke Bernhardt
Apr 25, 2000·Journal of Pediatric Hematology/oncology·B E SmallS S Winter

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