PMID: 9428483Jan 15, 1998Paper

Assessment of the expression of p53, MIB-1 (Ki-67 antigen), and argyrophilic nucleolar organizer regions in carcinoma of the extrahepatic bile duct

Cancer
T SutoK Saito

Abstract

The authors retrospectively examined the predictive value of p53, MIB-1, and the argyrophilic nucleolar organizer regions (AgNOR) and examined the relationships among them in carcinoma of the extrahepatic bile duct (EHBD). Formalin fixed, paraffin embedded specimens from 54 patients with EHBD carcinoma were immunostained with MIB-1 against the Ki-67 nuclear antigen and p53 by the avidin-biotin peroxidase complex method, using the antigen retrieval technique of heating tissue sections in a microwave oven. The AgNOR proteins were localized at the optical level, as shown by a one-step silver staining technique. MIB-1 and AgNOR were closely associated with lymph node metastasis (P < 0.01). The cumulative survival rate for patients with a low MIB-1 labeling index (LI) (< 29%) was significantly better than that for patients with a high MIB-1 LI (> or = 29%) in cases of EHBD carcinoma (P < 0.05), but MIB-1 was not an independent prognostic factor in multivariate analysis. The results indicated that AgNOR and p53 overexpression had no prognostic value. The authors detected p53 in 24 of the 54 EHBD carcinomas (44.4%). There was a significant correlation between MIB-1 and AgNOR (P < 0.01). The authors found that neither MIB-1 nor AgNOR c...Continue Reading

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Citations

Oct 28, 1999·The New England Journal of Medicine·P C de GroenD M Nagorney
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Karel CacaFrieder Berr
Apr 29, 2008·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Xiao-ran He, Xiao-peng Wu
Oct 22, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christopher D BriggsDavid P Berry
Feb 28, 2003·Surgical Oncology Clinics of North America·Asif Rashid
Jun 1, 2011·Journal of Applied Oral Science : Revista FOB·João Adolfo Costa HanemannMireile São Geraldo dos Santos Souza
Nov 14, 2000·Diagnostic Cytopathology·C J Stewart, G M Burke
Dec 18, 2001·British Journal of Cancer·A RaoufJ V Reynolds
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M HuiT Takayama
May 21, 2011·Journal of Gastrointestinal Cancer·Tarun Rustagi, Constantin A Dasanu
Nov 15, 2000·The American Journal of Surgical Pathology·A MaitraJ Albores-Saavedra

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