Assessment of the hypoxic-ischemic encephalopathy in neonates using non-invasive near-infrared spectroscopy

Physiological Measurement
Lan HuangFenghua Tian

Abstract

This paper introduces a method of monitoring cerebral oxygenation for healthy neonates and neonates with hypoxic-ischemic encephalopathy (HIE) using near-infrared spectroscopy. The object of this study was to investigate whether or not there were differences between the HIE group and the healthy group in terms of NIRS parameters. The subjects were all term neonates, their age ranging from 2 to 18 days. The healthy group included 25 subjects while the HIE group consisted of 16 patients. A prototype NIRS instrument, which provides the data of tissue oxygenation including regional oxygen saturation (rSO2), the increment of oxyhemoglobin concentration and hemoglobin (deltaHbO2 and deltaHb) was used, and the data of rSO2 was compared with the data from the blood gas analyzer. The result shows that: (1) the mean+/-SD of rSO2 for the healthy group was 62 +/- 4% in the frontal region under the quiet sleep condition, but the mean+/-SD of rSO2 for the HIE group was 53 +/- 3%. (2) As all subjects inhaled pure oxygen in 21 min(-1) for a period of 60 s, rSO2 for the healthy group increased rapidly, with the increase in rSO2 (deltarSO2) being 7 +/- 2.3%, but the increase in rSO2 for the HIE neonates was 3 +/- 1.5%. After inhaling oxygen, del...Continue Reading

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Citations

Nov 1, 2011·Journal of the Chinese Medical Association : JCMA·Jen-Chung ChienBetau Hwang
Nov 5, 2016·Frontiers in Pediatrics·Krishna Revanna GopagondanahalliAtul Malhotra
Aug 4, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anna Petrova, Rajeev Mehta
May 19, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gemma BaleIlias Tachtsidis
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Oct 27, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nadège Roche-LabarbePatricia Ellen Grant
Mar 7, 2007·Journal of the Chinese Medical Association : JCMA·Jen-Chung ChienBetau Hwang
Sep 6, 2020·Physiological Reports·Gemma BaleIlias Tachtsidis

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