PMID: 15334843Sep 1, 2004Paper

Assessment of the influence of fatty acids on indices of insulin sensitivity and myocellular lipid content by use of magnetic resonance spectroscopy in cats

American Journal of Veterinary Research
Caroline WilkinsM Hoenig

Abstract

To determine whether dietary fatty acids affect indicators of insulin sensitivity, plasma insulin and lipid concentrations, and lipid accumulation in muscle cells in lean and obese cats. 28 neutered adult cats. IV glucose tolerance tests and magnetic resonance imaging were performed before (lean phase) and after 21 weeks of ad libitum intake of either a diet high in omega-3 polyunsaturated fatty acids (3-PUFAs; n = 14) or high in saturated fatty acids (SFAs; 14). Compared with the lean phase, ad libitum food intake resulted in increased weight, body mass index, girth, and percentage fat in both groups. Baseline plasma glucose or insulin concentrations and glucose area under the curve (AUC) were unaffected by diet. Insulin AUC values for obese and lean cats fed 3-PUFAs did not differ, but values were higher in obese cats fed SFAs, compared with values for lean cats fed SFAs and obese cats fed 3-PUFAs. Nineteen cats that became glucose intolerant when obese had altered insulin secretion and decreased glucose clearance when lean. Plasma cholesterol, triglyceride, and non-esterified fatty acid concentrations were unaffected by diet. Ad libitum intake of either diet resulted in an increase in both intra- and extramyocellular lipid. ...Continue Reading

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Citations

Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Saskia KleyDarin E Olson
Sep 2, 2011·American Journal of Veterinary Research·Michal Mazaki-ToviPatricia A Schenck
Jun 29, 2012·American Journal of Veterinary Research·Margarethe HoenigDuncan C Ferguson
Aug 2, 2012·American Journal of Veterinary Research·Michal Mazaki-ToviPatricia A Schenck
Nov 18, 2011·Journal of the American Veterinary Medical Association·John E Bauer
May 4, 2013·Research in Veterinary Science·M H ClarkM Hoenig
Aug 12, 2008·Domestic Animal Endocrinology·E JordanM Hoenig
Dec 11, 2007·Veterinary Immunology and Immunopathology·Liliana Jaso-FriedmannMargarethe Hoenig
Aug 9, 2007·Domestic Animal Endocrinology·M HoenigD C Ferguson
Jan 18, 2013·Journal of Veterinary Internal Medicine·C E Lenox, J E Bauer
Jul 21, 2012·Journal of Animal Physiology and Animal Nutrition·T HäringB A Wichert
Mar 5, 2014·Journal of Veterinary Internal Medicine·M ClarkM Hoenig
Mar 13, 2014·The Journal of Small Animal Practice·M Mazaki-ToviP A Schenck
Jun 15, 2016·The Veterinary Clinics of North America. Small Animal Practice·Melissa Clark, Margarethe Hoenig
Jul 10, 2012·Journal of Diabetes Science and Technology·Margarethe Hoenig
Aug 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Margarethe Hoenig
Aug 12, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M HoenigD C Ferguson
Sep 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margarethe HoenigDarin E Olson
Jun 26, 2021·Journal of Feline Medicine and Surgery·Melissa Clark, Margarethe Hoenig

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