PMID: 18186334Jan 12, 2008Paper

Assessment of the interaction between aquatic colloids and pharmaceuticals facilitated by cross-flow ultrafiltration

Environmental Science & Technology
Khalid MaskaouiJohn L Zhou

Abstract

Interactions between pharmaceuticals and aquatic colloids are a key process regulating their environmental fate, but poorly understood. A validated cross-flow ultrafiltration (CFUF) system was used to isolate river colloids and to determine the partition of selected pharmaceuticals between colloidal (>1 kDa but <0.7 microm) and dissolved phases (<1 kDa) by liquid chromatography-tandem mass spectrometry (LC-MS-MS). The kinetics of pharmaceutical binding to colloids was rapid, reaching equilibrium within 5 min. The mass balance of chosen pharmaceuticals through CFUF system was satisfactory for propranolol, sulfamethoxazole, meberverine, carbamazepine, indomethacine, diclofenac, and meclofenamic acid. The partition coefficient normalized to colloidal organic carbon content (Kcoc) varied from 5.45 x 10(4) to 7.54 x 10(5) mL/g for the chosen pharmaceuticals, which are greater than those for endocrine disrupting chemicals (EDCs), suggesting substantially stronger colloidal interactions with pharmaceuticals than with EDCs. Linear relationships were demonstrated between log-Kcoc, and pharmaceutical properties such as log Kow (octanol-water partition coefficient), highlighting the importance of compound hydrophobicity in controlling the...Continue Reading

References

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Citations

Oct 22, 2008·Environmental Science and Pollution Research International·Bo PanBaoshan Xing
Dec 22, 2009·Environmental Science and Pollution Research International·Khalid Maskaoui, John L Zhou
Jan 9, 2013·Environmental Science & Technology·Kerry N McPhedranKen G Drouillard
Jul 26, 2014·Journal of Hazardous Materials·M I VasquezD Fatta-Kassinos
May 1, 2012·The Science of the Total Environment·Di WuBaoshan Xing
Jun 12, 2013·The Science of the Total Environment·Jonas MargotD A Barry
Jul 9, 2010·Environmental Pollution·Juan HouBaoshan Xing
Oct 5, 2013·Water Research·John Zhou, Nicola Broodbank
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Karim BenhabibHerman P van Leeuwen

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