PMID: 16522904Mar 9, 2006Paper

Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia

The American Journal of Clinical Nutrition
David J A JenkinsWilliam Singer

Abstract

Cholesterol-lowering foods may be more effective when consumed as combinations rather than as single foods. Our aims were to determine the effectiveness of consuming a combination of cholesterol-lowering foods (dietary portfolio) under real-world conditions and to compare these results with published data from the same participants who had undergone 4-wk metabolic studies to compare the same dietary portfolio with the effects of a statin. For 12 mo, 66 hyperlipidemic participants were prescribed diets high in plant sterols (1.0 g/1000 kcal), soy protein (22.5 g/1000 kcal), viscous fibers (10 g/1000 kcal), and almonds (23 g/1000 kcal). Fifty-five participants completed the 1-y study. The 1-y data were also compared with published results on 29 of the participants who had also undergone separate 1-mo metabolic trials of a diet and a statin. At 3 mo and 1 y, mean (+/-SE) LDL-cholesterol reductions appeared stable at 14.0 +/- 1.6% (P < 0.001) and 12.8 +/- 2.0% (P < 0.001), respectively (n = 66). These reductions were less than those observed after the 1-mo metabolic diet and statin trials. Nevertheless, 31.8% of the participants (n = 21 of 66) had LDL-cholesterol reductions of >20% at 1 y (x +/- SE: -29.7 +/- 1.6%). The LDL-cholest...Continue Reading

References

Aug 1, 1979·The American Journal of Clinical Nutrition·C R SirtoriD Kritchevsky
Oct 19, 1991·BMJ : British Medical Journal·L E RamsayP R Jackson
Jan 1, 1991·Circulation·K M AndersonW B Kannel
Jan 1, 1988·Drugs·D R Illingworth
Mar 20, 1986·The New England Journal of Medicine·S M Grundy
Nov 16, 1995·The New England Journal of Medicine·T A MiettinenE Vartiainen
Aug 3, 1995·The New England Journal of Medicine·J W AndersonM E Cook-Newell
Dec 1, 1994·The American Journal of Medicine·D B HunninghakeR R O'Connor
May 1, 1993·Metabolism: Clinical and Experimental·D J JenkinsH Stern
Dec 16, 1998·The American Journal of Clinical Nutrition·S M PotterJ W Erdman
Dec 24, 1998·JAMA : the Journal of the American Medical Association·D OrnishR J Brand
Sep 9, 1999·The American Journal of Clinical Nutrition·P M Kris-EthertonT D Etherton
Mar 24, 2000·BMJ : British Medical Journal·M Law
Jun 6, 2000·The American Journal of Clinical Nutrition·J W AndersonK W Weingand
Nov 25, 2000·Metabolism: Clinical and Experimental·D J JenkinsV Fulgoni
Jan 4, 2001·The New England Journal of Medicine·F M SacksUNKNOWN DASH-Sodium Collaborative Research Group
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Oct 31, 2002·European Journal of Clinical Investigation·A GeelenM B Katan
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
May 29, 2003·European Journal of Clinical Nutrition·H F J HendriksF Y Ntanios
Jul 24, 2003·JAMA : the Journal of the American Medical Association·David J A JenkinsPhilip W Connelly
Jul 24, 2003·JAMA : the Journal of the American Medical Association·James W Anderson
Jul 25, 2003·European Journal of Clinical Nutrition·R M Weggemans, E A Trautwein
Nov 19, 2003·Metabolism: Clinical and Experimental·David J A JenkinsPhilip W Connelly
Apr 28, 2004·Archives of Internal Medicine·Ira S OckeneJames R Hebert
Jul 13, 2004·The American Journal of Cardiology·George A BrayUNKNOWN DASH Collaborative Research Group

❮ Previous
Next ❯

Citations

Dec 22, 2006·The Journal of Nutrition·Peter J Gillies, Elaine S Krul
Oct 14, 2008·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Victoria Shanta RetelnyJulie L Roth
Mar 5, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Christos S DerdemezisMoses S Elisaf
Jul 7, 2011·Journal of the American College of Nutrition·James W Anderson, Heather M Bush
Oct 21, 2011·The British Journal of Nutrition·Emily SonestedtMarju Orho-Melander
Jun 21, 2011·Journal of Internal Medicine·C W C Kendall
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Amy J Lanou
Oct 6, 2016·Healthcare·Tracy L SchumacherClare E Collins
Sep 12, 2007·Basic & Clinical Pharmacology & Toxicology·Seema YousufFakhrul Islam
Mar 14, 2007·Current Opinion in Lipidology·Lewis H Kuller
Apr 14, 2010·The Journal of Cardiovascular Nursing·Lynne T Braun
Oct 15, 2010·The Journal of Nutrition·David J A JenkinsPenny M Kris-Etherton
Oct 17, 2012·Nutrition Research Reviews·Janice I Harland
Oct 17, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·J Michael Gonzalez-CampoyUNKNOWN American College of Endocrinology and the Obesity Society
Jun 2, 2018·Journal of Nutrition and Metabolism·Jay T SutliffeJulia C Scheid
Apr 26, 2007·European Journal of Clinical Nutrition·D J A JenkinsW Singer
Dec 1, 2006·European Journal of Clinical Nutrition·D J A JenkinsW Singer
May 24, 2006·Expert Review of Cardiovascular Therapy·Rodolfo PaolettiAndrea Cignarella
Dec 9, 2009·The Proceedings of the Nutrition Society·Amin EsfahaniCyril W C Kendall
Aug 3, 2014·Current Diabetes Reports·Gabrielle Turner-McGrievy, Metria Harris
Nov 15, 2015·Advances in Nutrition·Chesney K RichterPenny M Kris-Etherton
Apr 2, 2008·Current Atherosclerosis Reports·David J A JenkinsCyril W C Kendall
Jan 15, 2011·Current Opinion in Lipidology·Eric Bruckert, David Rosenbaum
Sep 22, 2016·Current Cardiology Reports·Peter L ZockGerard Hornstra
Feb 5, 2021·Journal of the American College of Cardiology·Arrigo F G CiceroAlberto Zambon
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Andrea J GlennJordi Salas-Salvadó

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.