Assessment of the Model for End-stage Liver Disease (MELD) Score in Predicting Prognosis of Patients with Alcoholic Hepatitis

Journal of Clinical and Experimental Hepatology
Sundeep K GoyalJayant K Ghosh

Abstract

Traditionally, Maddrey discriminant function (DF) score has been used for stratifying the prognosis of alcoholic hepatitis. Recently, the Model for end-stage liver disease (MELD) score has been applied to alcoholic hepatitis and some investigators consider MELD score as a better prognostic indicator. Another new prognostic approach, Lille model has been also suggested to accurately identify patients at high risk of death. Therefore, this prospective study was aimed to compare MELD, DF, Child-Turcotte-Pugh (CTP) scores and Lille model for predicting the short-term mortality in Indian patients with alcoholic hepatitis. We calculated the DF, CTP, MELD and Lille scores in patients hospitalized with alcoholic hepatitis & evaluated if the scores predicted in-hospital mortality. A total of 104 patients were enrolled and thirty-two (30.7%) patients died during the hospitalization (2-30 days). Admission DF score (OR 1.1, P < 0.04), CTP (OR 2, P < 0.05) MELD score (OR 2.2, P < 0.005) and first week MELD score (OR 1.1, P < 0.05) were independently associated with in-hospital mortality. The area under the receiver-operating curve (AUROC) for the admission and day 7 MELD score was significantly higher than CTP score and was comparable to DF...Continue Reading

References

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Nov 11, 2011·The New England Journal of Medicine·Philippe MathurinJean-Charles Duclos-Vallée

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Citations

Apr 29, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ravi DaswaniAnil Arora
Jun 20, 2017·European Journal of Gastroenterology & Hepatology·Samuel R FernandesJosé Velosa
Jun 17, 2019·Current Gastroenterology Reports·Kelly E Diaz, Thomas D Schiano
Nov 30, 2016·World Journal of Gastroenterology : WJG·Hee Yeon KimUNKNOWN Korean Acute-on-Chronic Liver Failure Study Group

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