Assessment of the onset of lotilaner (Credelio™) speed of kill of fleas on dogs

Parasites & Vectors
Daniela CavalleriSteve Nanchen

Abstract

Lotilaner (Credelio™) is the newest member of the novel isoxazoline chemical class to be developed to treat canine ectoparasitism. Administered orally, lotilaner is rapidly absorbed with peak blood levels occurring within 2 h post-treatment. A study was undertaken to determine the earliest onset of lotilaner's efficacy against existing flea infestations. From 72 Beagles, 64 qualifying dogs were ranked in descending order of flea counts from a Day -8 infestation and placed into eight blocks. Within blocks, eight dogs were randomly allocated among eight groups: Groups 1 to 4 were treated orally with lotilaner, at as close as possible to the minimum dose rate of 20 mg/kg within 30 (± 5) minutes after feeding; Groups 5 to 8 were untreated controls. All dogs were infested with 100 ± 5 fleas on Day -2, and whole-body flea counts were completed at 30 min and one, two and 8 h after treatment. Efficacy calculations were based on arithmetic and geometric means if an adequate infestation (at least six of eight untreated dogs with a flea retention of ≥ 50%) was demonstrated in the equivalent control group. Adequate infestations were established in all control groups. At 30 min and 1 h post-treatment, relative to the matching untreated cont...Continue Reading

References

Jan 1, 1997·Annual Review of Entomology·M K Rust, M W Dryden
Nov 2, 2017·Parasites & Vectors·Céline E ToutainMartin Jung
Nov 2, 2017·Parasites & Vectors·Daniela CavalleriSteve Nanchen

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Citations

Nov 2, 2017·Parasites & Vectors·Daniela CavalleriSteve Nanchen
Nov 2, 2017·Parasites & Vectors·Céline E ToutainMartin Jung
Nov 2, 2017·Parasites & Vectors·Susan E Little
Oct 3, 2020·Insects·Michael K Rust
Jul 14, 2018·Parasites & Vectors·Céline E ToutainMartin Jung
Jul 14, 2018·Parasites & Vectors·Emmanuelle A Kuntz, Srinivas Kammanadiminti
Mar 19, 2021·Journal of Veterinary Pharmacology and Therapeutics·Xueying ZhouWalter H Hsu

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