PMID: 9177966Apr 1, 1997Paper

Assessment of the oxacillin disk screening test for determining penicillin resistance in Streptococcus pneumoniae

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
G V DoernG Pierce

Abstract

The 1 microgram oxacillin disk diffusion screening test was performed on 1516 recent clinical isolates of Streptococcus pneumoniae obtained in a 1994-1995 U.S. surveillance study and the results compared to penicillin MICs determined using a standardized broth microdilution method. The oxacillin disk screening method failed to distinguish penicillin-resistant strains from those that were intermediately susceptible. Furthermore, a high percentage (11.1%) of penicillin-susceptible strains, for which MICs of penicillin were usually 0.06 or 0.03 microgram/ml, yielded zone diameters of < or = 19 mm with the oxacillin screen test and thus would have been falsely categorized as being resistant to penicillin.

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Citations

Feb 9, 2006·International Journal of Antimicrobial Agents·Marwan UwaydahThomas Rohban

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