PMID: 9540054Apr 16, 1998Paper

Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods

Journal of Neuro-oncology
N MiyazawaM Diksic

Abstract

This study was designed to evaluate the density of peripheral benzodiazepine receptor (PBR) sites as a function of tumor malignancy in human gliomas, and to compare the results obtained with autoradiographic and liquid scintillation measurements performed on the same tissue specimens. In vitro binding of [3H]PK-11195[1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3-isoguinol ine carboxamide] to human gliomas in radioligand binding studies revealed a significantly higher level (about 3 fold) of PBR binding sites in both low grade and high grade gliomas as compared to normal cortex. The Bmax (mean +/- SD) of high and low grade gliomas, when entire tissue sections were measured by autoradiography, was 5.5 +/- 0.3 pmol/mg-tissue (n = 5) and 1.8 +/- 0.9 pmol/mg-tissue (n = 6), respectively, although it was evident that there was area of hot spots in the high grade tumors. This difference was significant (p < 0.05; two-tailed t-test). Similarly, the KD values (dissociation constant; nM) between the high (KD = 20.4 +/- 1.3 nM) and low (KD = 14.3 +/- 2.1 nM) grade gliomas were significantly different. A significant difference in binding site density (Bmax) between the two types of gliomas was also obtained in liquid scintillation measure...Continue Reading

Citations

Jul 26, 2018·International Journal of Molecular Sciences·Nimisha H BhoolaZodwa Dlamini
Jul 27, 2001·Fundamental & Clinical Pharmacology·J LavickaL Mirossay
Dec 20, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paul CummingRichard Banati
Apr 29, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David R OwenChristine A Parker
Nov 10, 2015·Biochemical Society Transactions·Eryn L WerryMichael Kassiou
Mar 6, 2010·Molecular and Cellular Biochemistry·Sutapa MukhopadhyaySalil K Das
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sylvaine GaliègueJoelle Simony-Lafontaine
Mar 16, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Bastian ZinnhardtAlexandra Winkeler
May 18, 2006·Bioconjugate Chemistry·H Charles ManningDarryl J Bornhop

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