Assessment of the pharmacological interactions between the nematodicidal fenbendazole and the flukicidal triclabendazole: In vitro studies with bovine liver microsomes and slices

Journal of Veterinary Pharmacology and Therapeutics
P VivianiG Virkel

Abstract

Parasitic diseases have a significant impact on livestock production. Nematodicidal drugs, such as fenbendazole (FBZ) or its oxidized metabolite oxfendazole (OFZ), can be used along with the trematodicidal triclabendazole (TCBZ), to broaden the spectrum of anthelmintic activity. However, co-exposure to these compounds could lead to drug-drug (D-D) interactions and eventually alter the clinical profile of each active principle. The aim of this study was to assess the presence of such interactions by means of two in vitro models, namely bovine liver microsomal fractions and bovine precision-cut liver slices (PCLSs). To this end, an in vitro assessment involving incubation of FBZ and TCBZ or a combination of FBZ and TCBZ was carried out. Results with microsomal fractions showed a 78.4% reduction (p = .002) in the rate of OFZ production upon co-incubation, whereas the sulfoxide metabolite of TCBZ (TCBZSO) exhibited a decreasing tendency. With PCLS, OFZ accumulation in the incubation medium increased 1.8-fold upon co-incubation, whereas TCBZSO accumulation decreased by 28%. The accumulation of FBZ and OFZ in the liver tissue increased upon 2-hr co-incubation, from 2.1 ± 1.5 to 18.2 ± 6.1 (p = .0009) and from 0.4 ± 0.1 to 1.3 ± 0.3 n...Continue Reading

References

Dec 1, 1986·Journal of Veterinary Pharmacology and Therapeutics·N A Mohammed AliR J Richards
May 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C VillaverdeJ G Prieto
Jan 1, 1993·Drug Metabolism Reviews·C E Lanusse, R K Prichard
Jun 7, 2003·Toxicology and Applied Pharmacology·Esther F A BrandonJan H M Schellens
Feb 18, 2004·Current Drug Metabolism·Jeevan R Kunta, Patrick J Sinko
Apr 22, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·G VirkelC Lanusse
Apr 1, 1990·Parasitology Today·W C Campbell
Feb 11, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gracia MerinoAlfred H Schinkel
May 4, 2006·Journal of Veterinary Pharmacology and Therapeutics·G VirkelC Lanusse
Aug 23, 2006·Expert Opinion on Drug Metabolism & Toxicology·Marc VermeirGeert Mannens
Mar 19, 2008·Toxicology and Applied Pharmacology·M G L ElferinkG M M Groothuis
Aug 2, 2008·Biochemical Pharmacology·Laura MatéCarlos Lanusse
Jul 8, 2009·Applied Biochemistry and Biotechnology·Sepuri Asha, Maravajhala Vidyavathi
Jan 1, 2002·Toxicology Mechanisms and Methods·Robyn L FisherKlaus Brendel
Jun 2, 2010·Chemico-biological Interactions·Jacques DupuyAnne Lespine
Dec 21, 2010·Trends in Parasitology·Ian A Sutherland, Dave M Leathwick
Mar 23, 2011·Toxicology and Applied Pharmacology·M G L ElferinkG M M Groothuis
Sep 3, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Harriet NamwanjeAnnette Olsen
Apr 18, 2012·Antimicrobial Agents and Chemotherapy·Borja BarreraGracia Merino
Dec 10, 2013·Veterinary Parasitology·Carlos LanusseAdrian Lifschitz
Jan 30, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·María Laura MatéGuillermo Virkel
Jun 25, 2016·Acta Tropica·Luis Fernando Viana FurtadoÉlida Mara Leite Rabelo
Oct 22, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Paula VivianiGuillermo L Virkel

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.