Assessment of the potential of growth factors for localized alveolar ridge augmentation: a systematic review

Journal of Clinical Periodontology
Ronald E JungChristoph H F Hammerle

Abstract

To systematically assess the literature regarding the clinical, histological, and radiographic outcome of bone morphogenetic proteins (BMP-2, BMP-7), growth/differentiation factor-5 (GDF-5), platelet-derived growth factor (PDGF), and parathyroid hormone (PTH) for localized alveolar ridge augmentation. Five separate Medline searches were performed in duplicate for human and animal studies, respectively. The primary outcome of the included studies was bone regeneration of localized alveolar ridge defects or craniofacial defects. In six human studies, BMP-2 affected local bone augmentation with increasing volume for higher doses. A majority (43 of 45) of animal studies using BMP-2 showed a positive effect in favour of the growth factor (GF). In six of eight studies, a positive effect was associated with the use of BMP-7. Only one animal study was included for GDF-5 revealing statistically significantly higher bone volume. Regarding PDGF, statistically significantly higher bone volume was observed in five of 10 included studies. Four animal studies using PTH revealed statistically significantly more bone regeneration compared with controls. Differing levels and quantity of evidence were noted to be available for the GFs evaluated, ...Continue Reading

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Citations

Feb 9, 2012·Journal of Materials Science. Materials in Medicine·Ling XuFuqiang Zhang
Dec 8, 2009·Journal of Periodontology·Ludovico SbordonePaolo Toti
Jul 20, 2013·Tissue Engineering. Part B, Reviews·Nattharee ChanchareonsookJohn A Jansen
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Apr 16, 2011·Oral and Maxillofacial Surgery Clinics of North America·Patrick J Louis
Sep 2, 2009·Clinical Oral Implants Research·João Paulo Mardegan IssaRubens Ferreira de Albuquerque
Sep 2, 2009·Clinical Oral Implants Research·Frank SchwarzJürgen Becker
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Aug 4, 2011·Clinical Oral Implants Research·Martin FreilichLiisa Kuhn
Nov 19, 2011·Journal of Clinical Periodontology·Jingxiao WangGang Wu
May 20, 2011·Australian Dental Journal·I Darby
Oct 30, 2013·Journal of Clinical Periodontology·Jesús Torres García-DencheFaleh Tamimi
Aug 21, 2014·Journal of Clinical Periodontology·Po-Chun ChangTsai Sheng-Chueh
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Jul 3, 2013·Clinical Implant Dentistry and Related Research·Siddharth Shanbhag, Vivek Shanbhag
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Nov 2, 2013·The Journal of Oral Implantology·Rosa-María Díaz-SánchezDaniel Torres-Lagares
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Sep 13, 2019·Clinical Oral Implants Research·Javier Sanz-EsporrinMariano Sanz
Jul 22, 2014·Clinical Oral Implants Research·Phillipp BrockmeyerRudolf Matthias Gruber
Aug 24, 2017·European Journal of Oral Sciences·Ibrahim ElgaliPeter Thomsen

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