PMID: 8970878Dec 1, 1996Paper

Assessment of the progression of emphysema by quantitative analysis of spirometrically gated computed tomography images

Investigative Radiology
H ZagersJ H Reiber

Abstract

The authors assessed the progression of pulmonary emphysema by means of quantitative analysis of computed tomography images. Twenty-three patients suffering from emphysema due to an alpha 1-antitrypsin deficiency, aged 45 +/- 7 years and exsmokers, were scanned twice with a 1-year time interval. At 90% of the vital lung capacity, slices with a thickness of 1.5 mm were acquired at the level of the carina and 5 cm above the carina; slices with a thickness of 1 cm were acquired 5 cm below the carina. The entire lung was scanned spirally at a respiratory status, corresponding with 75% of the total lung capacity at baseline. The mean lung densities (MLD) were calculated in an objective manner with new analytic software featuring automated detection of the lung contours. Mean lung densities decreased by 14.2 +/- 12.0 Hounsfield units (HU; P < 0.001) above the carina, by 18.1 +/- 14.4 HU (P < 0.001) at the carina level, by 23.6 +/- 15.0 HU (P < 0.001) below the carina, and by 12.8 +/- 22.2 HU (P < 0.01) for the entire lung. The decrease in MLD was most obvious in the lower lung lobes. For the same patient group, the annual decrease in the forced expiratory volume (FEV1) and the carbon monoxide-diffusion were 120 +/- 190 mL (P < 0.01) ...Continue Reading

References

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Citations

Oct 19, 2004·European Journal of Radiology·Mubeccel ArslanIsmail Salk
Jan 10, 2004·Medical Physics·Ingrid C SluimerBram van Ginneken
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·R UppaluriG McLennan
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·A DirksenJ Stolk
Oct 3, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Jan 14, 2009·Proceedings of the American Thoracic Society·Harvey O Coxson
Aug 11, 2009·Thoracic Surgery Clinics·Jonathan G Goldin, Fereidoun Abtin
Dec 9, 2008·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Manish Kakar, Dag Rune Olsen
Oct 1, 2008·The Clinical Respiratory Journal·A Dirksen
Aug 25, 2011·AJR. American Journal of Roentgenology·Brad M KellerDavid F Yankelevitz
May 23, 2008·Investigative Radiology·Balaji GaneshanChris R Chatwin
Aug 26, 2009·Journal of Thoracic Imaging·Jonathan G Goldin
May 28, 2016·The European Respiratory Journal·Kristoffer Ostridge, Tom M A Wilkinson
Jul 2, 2016·The European Respiratory Journal·William MacNee
Mar 5, 2020·AJR. American Journal of Roentgenology·Andreas M FischerU Joseph Schoepf

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