Assessment of the red blood cell proteome in a dog with unexplained hemolytic anemia

Veterinary Clinical Pathology
Victoria L BlackAndrew D Davidson

Abstract

A 7-year-old female neutered Jack Russell Terrier was presented to Langford Vets, the University of Bristol, with a history of chronic intermittent lethargy. Investigations and clinical course were compatible with hereditary hemolysis due to a red blood cell membrane defect. Proteomics was used to explore protein alterations in the presence of a hypothesized red blood cell membrane protein deficiency. Proteomic analysis revealed downregulation of the band 3, and alpha- and beta-adducin proteins, and alterations in the red blood cell proteome consistent with previous reports of changes due to the presence of reticulocytosis and ongoing hemolysis. The spectrum of protein alterations identified in the affected dog may be homologous to a band 3 protein deficiency secondary to hereditary spherocytosis, as described in people.

References

Jan 11, 2000·Journal of the American Veterinary Medical Association·B KohnU Giger
Nov 25, 2004·Hematology·Wendell F RosseAlan D Schreiber
Apr 9, 2005·European Journal of Haematology·S RochaA Santos-Silva
Nov 24, 2005·Hematology·Patrick G Gallagher
May 30, 2006·Blood Reviews·Jean Delaunay
Feb 22, 2007·Veterinary Clinical Pathology·Jessica E PrenniChristine S Olver
Oct 23, 2008·Lancet·Silverio PerrottaNarla Mohandas
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jun 23, 2009·Journal of Proteomics·Erica M PasiniAlan W Thomas
Mar 31, 2010·Seminars in Hematology·Juan C Gea-Banacloche
Jun 28, 2011·Molecular Biology Reports·Selen PekerDuygu Ozel Demiralp
Nov 8, 2011·British Journal of Haematology·Paula H B Bolton-MaggsUNKNOWN General Haematology Task Force of the British Committee for Standards in Haematology
May 29, 2012·Blood Cells, Molecules & Diseases·Jessica E PrenniChristine S Olver
Jun 27, 2012·Molecular BioSystems·Chantana PolprasertVisith Thongboonkerd
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen
May 15, 2013·Blood Reviews·Lydie Da CostaNarla Mohandas
Oct 17, 2013·Biochimica Et Biophysica Acta·Benjamin Barasa, Monique Slijper
May 30, 2015·Journal of Feline Medicine and Surgery·Claudia TritschlerUrs Giger
Mar 24, 2016·Molecular & Cellular Proteomics : MCP·Marieangela C WilsonJan Frayne
Jun 14, 2016·British Journal of Haematology·Archana M AgarwalRobert D Christensen

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