Assessment of the role of transcript for GATA-4 as a marker of unfavorable outcome in human adrenocortical neoplasms

BMC Endocrine Disorders
Angela S BarbosaChin J Lin

Abstract

BACKGROUND: Malignant neoplasia of the adrenal cortex is usually associated with very poor prognosis. When adrenocortical neoplasms are diagnosed in the early stages, distinction between carcinoma and adenoma can be very difficult to accomplish, since there is yet no reliable marker to predict tumor recurrence or dissemination. GATA transcription factors play an essential role in the developmental control of cell fate, cell proliferation and differentiation, organ morphogenesis, and tissue-specific gene expression. Normal mouse adrenal cortex expresses GATA-6 while its malignant counterpart only expresses GATA-4. The goal of the present study was to assess whether this reciprocal change in the expression of GATA factors might be relevant for predicting the prognosis of human adrenocortical neoplasms. Since human adrenal cortices express luteinizing hormone (LH/hCG) receptor and the gonadotropins are known to up-regulate GATA-4 in gonadal tumor cell lines, we also studied the expression of LH/hCG receptor. METHODS: We conducted a study on 13 non-metastasizing (NM) and 10 metastasizing/recurrent (MR) tumors obtained from a group of twenty-two adult and pediatric patients. The expression of GATA-4, GATA-6, and LH/hCG receptor (LHR...Continue Reading

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Citations

May 28, 2014·Cancer Science·Kiyoshi TakagiTakashi Suzuki
Mar 16, 2005·Molecular and Cellular Endocrinology·Sanne KiiveriMarkku Heikinheimo
Mar 6, 2007·Molecular and Cellular Endocrinology·Susanna VuorenojaNafis A Rahman
Jan 9, 2007·Molecular and Cellular Endocrinology·Helka ParviainenMarkku Heikinheimo
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Dec 12, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Helena Panteliou Lima-ValassiChin Jia Lin
Dec 12, 2020·Pediatric Blood & Cancer·Elisa ZambaitiCalogero Virgone

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Methods Mentioned

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