Assessment of the skin penetration properties of different carrier vehicles for topically applied cortisol

The British Journal of Dermatology
P J Ayres, G Hooper

Abstract

Four commercially available topical preparations of cortisol, Alphaderm, Calmurid HC, Efcortelan and Topisone, had trace quantities of tritiated cortisol added to them. The resultant radiolabelled creams were applied to the dorsum of the pig and the penetration of the steroid was assessed. Alphaderm was shown to deliver approximately 16.0 times more cortisol to the skin than Topisone, approximately 8.0 times more than Efcortelan and approximately 3.0 times more than Calmurid HC.

References

Apr 1, 1975·The Journal of Cell Biology·P M Elias, D S Friend
Mar 1, 1972·The Journal of Investigative Dermatology·M J BartekH I MAIBACH
Mar 15, 1967·Annals of the New York Academy of Sciences·H I MAIBACH, R J FELDMANN
May 1, 1966·Biochemistry·S L Hsia, Y L Hao
Jun 1, 1965·Archives of Dermatology·R J FELDMANN, H I MAIBACH

Citations

Jun 1, 1979·The British Journal of Dermatology·N A OrrE A Hill
May 1, 1989·Journal of the American Academy of Dermatology·D B JacksonJ D Guin
Dec 31, 2005·Journal of the American Academy of Dermatology·Ulrich R HenggeMichael J Cork
Jul 17, 2008·Expert Opinion on Pharmacotherapy·Jason E Frangos, Alexa B Kimball
Feb 1, 1982·The Veterinary Clinics of North America. Small Animal Practice·D W Scott
Feb 23, 2012·Skin Pharmacology and Physiology·H C KortingW Wigger-Alberti
Nov 1, 2018·Dermatologic Therapy·Leonardo Celleno
Feb 5, 2005·American Journal of Veterinary Research·Paul C MillsSheree E Cross

Related Concepts

Administration, Topical
Metazoa
Anti-Inflammatory Agents
Cytochemistry
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
Skin
Skin Absorption
Family suidae
Pharmaceutical Vehicles

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