Assessment of the sources of error affecting the quantitative accuracy of SPECT imaging in small animals.

Physics in Medicine and Biology
Andrew B HwangBruce H Hasegawa

Abstract

Small animal SPECT imaging systems have multiple potential applications in biomedical research. Whereas SPECT data are commonly interpreted qualitatively in a clinical setting, the ability to accurately quantify measurements will increase the utility of the SPECT data for laboratory measurements involving small animals. In this work, we assess the effect of photon attenuation, scatter and partial volume errors on the quantitative accuracy of small animal SPECT measurements, first with Monte Carlo simulation and then confirmed with experimental measurements. The simulations modeled the imaging geometry of a commercially available small animal SPECT system. We simulated the imaging of a radioactive source within a cylinder of water, and reconstructed the projection data using iterative reconstruction algorithms. The size of the source and the size of the surrounding cylinder were varied to evaluate the effects of photon attenuation and scatter on quantitative accuracy. We found that photon attenuation can reduce the measured concentration of radioactivity in a volume of interest in the center of a rat-sized cylinder of water by up to 50% when imaging with iodine-125, and up to 25% when imaging with technetium-99m. When imaging wi...Continue Reading

References

Jan 22, 1998·Physics in Medicine and Biology·T S PanM A King
Nov 20, 2001·Medical & Biological Engineering & Computing·C C HsuC Lee
Nov 7, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Jan BooijPieter Voorn
Aug 29, 2003·Current Opinion in Biotechnology·Joel R Cherry, Ana L Fidantsef
Dec 3, 2003·Molecular Imaging·Andreas Markus Loening, Sanjiv Sam Gambhir
Jan 27, 2004·Nuclear Medicine and Biology·Roelof J BenninkAnje A te Velde
Jun 15, 2004·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·William P SegarsStuart S Berr
Aug 12, 2005·IEEE Transactions on Medical Imaging·Yong DuEric C Frey
Sep 15, 2005·Journal of Cardiovascular Pharmacology·Ting-Ting HongBenedict R Lucchesi
Nov 3, 2005·Physics in Medicine and Biology·Steven R MeikleRichard B Banati
Nov 4, 2005·Medical Physics·Andrew B Hwang, Bruce H Hasegawa
Jul 13, 2006·European Journal of Nuclear Medicine and Molecular Imaging·F ForrerM de Jong
Jan 1, 1982·IEEE Transactions on Medical Imaging·L A Shepp, Y Vardi

❮ Previous
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Citations

Feb 17, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Christian VanhoveTony Lahoutte
May 8, 2009·European Journal of Nuclear Medicine and Molecular Imaging·M PissarekN Schramm
Jan 14, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Reza GolestaniRiemer H J A Slart
Jul 14, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Rajesh R PatilHai-Quan Mao
Aug 20, 2011·Physics in Medicine and Biology·Lindsay C JohnsonTodd E Peterson
May 24, 2011·International Journal of Molecular Imaging·Magdy M KhalilWilly Gsell
Apr 15, 2011·International Journal of Molecular Imaging·Bryan W ReutterGrant T Gullberg
Oct 16, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Sina TavakoliMehran M Sadeghi
May 3, 2013·Medical Physics·F SánchezW M Leevy
Jun 26, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Chao WuFreek J Beekman
May 24, 2011·International Journal of Molecular Imaging·Ciara M FinucaneStephen J Mather
Jul 11, 2013·Computational and Mathematical Methods in Medicine·Hsin-Hui Lee, Jyh-Cheng Chen
Dec 2, 2015·Molecular Pharmaceutics·Christopher G EnglandWeibo Cai
Aug 17, 2011·Nuclear Medicine and Biology·Dengfeng ChengDonald J Hnatowich
Mar 22, 2012·Contrast Media & Molecular Imaging·Lode R GoethalsTony Lahoutte
Nov 26, 2013·IEEE Transactions on Nuclear Science·Dan MaTaly Gilat Schmidt
Jun 13, 2016·Nuclear Medicine and Biology·Frans van der HaveFreek J Beekman
May 18, 2010·Nature Materials·Sung You HongBenjamin G Davis
Nov 18, 2014·Physics in Medicine and Biology·Carmen BouckaertRoel Van Holen
May 8, 2020·Nuclear Medicine and Molecular Imaging·Arun GuptaJae Sung Lee
Apr 5, 2013·Physics in Medicine and Biology·M BreuillyJ Darcourt
Jun 28, 2011·Physics in Medicine and Biology·Brian F HuttonFreek J Beekman
May 17, 2017·Journal of Applied Clinical Medical Physics·Shabnam Khorasani GerdekoohiMohammad Reza Ay
Sep 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Benjamin L FrancBruce H Hasegawa
Jan 4, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mathias LukasWinfried Brenner

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