Assessment of thyroid function in two hundred patients with beta-thalassemia major

Thyroid : Official Journal of the American Thyroid Association
Athanasios ZervasGeorge Tolis

Abstract

Despite improved hematologic care, multiendocrine dysfunction is a common complication of homozygous transfusion-dependent beta-thalassemia. In this study our goal was to estimate the prevalence of thyroid dysfunction in a large homogenous group of thalassemic patients. Two hundred patients with beta-thalassemia major (100 males and 100 females; mean age, 23.2 +/- 6.7 years; age range 11-43 years), regularly transfused and desferioxamine chelated, were randomly selected from a pool of approximately 800 patients with beta-thalassemia followed in our department. Thyroid function and iron-load status were evaluated by measurements of free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH), and serum ferritin levels. Of the subgroup of patients who proved to have normal thyroid hormone values, 26 (12 males, 14 females; mean age, 23.6 +/- 6.8 years; age range, 15-36 years) were randomly selected and underwent a standard TRH stimulation test. Thyroid dysfunction was defined as follows: overt hypothyroidism: low FT4 and/or FT3, increased TSH levels; subclinical hypothyroidism: normal FT4, FT3, increased TSH levels; exaggerated TSH response: normal FT4, FT3, normal basal TSH, deltaTSH > or = 21 microIU/mL (TSH levels measu...Continue Reading

References

Jan 1, 1990·Acta Haematologica·S MagroV De Santis
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B R Bacon, R S Britton
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·A MasalaA F Milia
Apr 1, 1984·Clinical Endocrinology·C PhenekosK Politou
Apr 1, 1993·Journal of Tropical Pediatrics·A al-HaderS Khatib

❮ Previous
Next ❯

Citations

Jan 14, 1999·British Journal of Haematology·C E JensenB Wonke
Jan 1, 2014·The Journal of the Egyptian Public Health Association·Abdel-Rahman A Abdel-RazekEman R Youness
May 7, 2010·Journal of Pediatric Hematology/oncology·Mohammad Reza Safarinejad
Sep 8, 2011·Asian Journal of Transfusion Science·Mohammed Saied AbdulzahraMahdi Muhammed Ridha
Feb 13, 2013·Clinical Medicine Insights. Cardiology·Taysir S GaradahDas S Nagalla
Mar 6, 2010·Journal of Endocrinological Investigation·M Delvecchio, L Cavallo
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Giampaolo PapiElio Roti
Jun 15, 2011·Expert Review of Hematology·Caterina Borgna-Pignatti, Maria Rita Gamberini
May 24, 2014·Pediatric Hematology and Oncology·Pamir IsikBahattin Tunc
Aug 14, 2003·BMC Endocrine Disorders·Alireza Abdollah ShamshirsazBagher Larijani
Nov 10, 2007·Endocrine Reviews·Bernadette Biondi, David S Cooper
Apr 25, 2008·Pediatric Hematology and Oncology·A MehrvarP Vossough
Apr 23, 2019·Journal of Pediatric Hematology/oncology·Adel BaghersalimiSetila Dalili
Oct 12, 2018·International Journal of Pediatrics·Suraj Haridas UpadyaNutan Kamath
Jun 11, 2016·Biomedical Reports·Ahmed Al-AkhrasMarwa Zakaria
Jun 6, 2018·International Journal of Endocrinology and Metabolism·Ali BaziMojtaba Delaramnasab

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.