Assessment of TNFA polymorphisms at positions -857 and -863 in Polish peptic ulcer patients

Advances in Medical Sciences
Aleksandra Sałagacka-KubiakEwa Balcerczak

Abstract

Peptic ulceration connected with chronic inflammation in gastrointestinal mucosa could be induced by Helicobacter pylori infection. Tumor necrosis factor alpha (TNF-α) encoded by TNFA gene is a key mediator in the inflammation process. There are several polymorphisms in the promoter of TNFA influencing its transcriptional activity. -857C>T (rs1799724) and -863C>A (rs1800630) substitutions may be responsible for increased TNFA transcription and TNF-α production. The association of these two polymorphisms with peptic ulceration and the development of H. pylori infection in peptic ulcer patients in Poles were evaluated. Polymorphisms were assessed by PCR-RFLP in 203 peptic ulcer patients. H. pylori infection was confirmed by rapid urease test. The results of genotyping were compared with those obtained for 248 healthy Polish individuals. There were no significant differences in genotype and allele frequencies for both investigated polymorphisms between peptic ulcer patients and healthy individuals. No associations between frequencies of particular genotypes and alleles for both SNPs and the presence of H. pylori infection in peptic ulcer patients and in subgroups of peptic ulcer women and men were confirmed. The investigated SNPs ...Continue Reading

References

Mar 21, 1998·European Journal of Clinical Investigation·S M HerrmannF Cambien
Apr 29, 1998·Archives of Internal Medicine·I RäihäL Sourander
Jun 28, 2005·Cancer Letters·Ja Young LeeJae Young Yoo
Sep 17, 2005·International Journal of Immunogenetics·M A Garcia-GonzalezA Lanas
Jul 25, 2009·International Journal of Cancer. Journal International Du Cancer·Oswaldo Partida-RodríguezMartha Perez-Rodríguez
Aug 8, 2009·Journal of Digestive Diseases·Anne-Marie Shanks, Emad M El-Omar
Aug 18, 2009·Lancet·Peter MalfertheinerKenneth E L McColl
Jan 5, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Stephen C Gilliver
Mar 12, 2010·World Journal of Gastroenterology : WJG·Mitsushige SugimotoTakahisa Furuta
Dec 17, 2010·World Journal of Gastrointestinal Oncology·Asahi HishidaNobuyuki Hamajima

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