Assessment of toxicity and differential antimicrobial activity of methanol extract of rhizome of Simaba ferruginea A. St.-Hil. and its isolate canthin-6-one

Journal of Ethnopharmacology
Vanessa Fátima GazoniDomingos Tabajara de Oliveira Martins

Abstract

Simaba ferruginea A. St.-Hil., Simaroubaceae, popularly known as "calunga" is a typical subtropical shrub used in Central Brazil mainly for infection, anti-inflammatory, analgesic and gastric duodenal-ulcers. It presents in its composition the alkaloid canthin-6-one, an alkaloid indole β-carboxylic. This study aims to investigate the toxicity, antimicrobial activities of methanol extract of Simaba ferruginea (MESf) and canthin-6-one by using different experimental models. The present study evaluated the phytochemical analysis by high performance liquid chromatography (HPLC), toxicological potential of MESf and canthin-6-one, using the cytotoxicity, genotoxicity assays with CHO-K1 cells and in vivo acute test in mice. Antimicrobial activity was evaluated by the broth microdilution assays, while the antimicrobial mechanism of action was also assessed using different in vitro bacterial and fungal models. The HPLC analysis of MESf revealed the presence of canthin-6-one, kaempferol and morin. Differential in vitro toxicities were observed between MESf and canthin-6-one. In the cytotoxicity assay, MESf presented toxicity against CHO-K1, while canthin-6-one did not. In the case of in vitro genotoxicity, both showed to be potentially g...Continue Reading

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Citations

May 3, 2019·Journal of Asian Natural Products Research·Ming-Zao ZhaoBei Jiang
Jun 20, 2020·Archiv der Pharmazie·Yang LiuGuishun Piao
Mar 2, 2021·Biochemical Pharmacology·Karuppusamy ArunachalamDomingos Tabajara de Oliveira Martins
Apr 12, 2021·Journal of Oral Biosciences·William NguyenDalia Seleem

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