Assessment of toxicity and mutagenicity in air particulate matter from an urban industrial area in the coast of the Rio de la Plata

Environmental Toxicology
A MüllerAlicia Ronco

Abstract

Chemical characterization and effects assessment of semivolatile organic compounds in organic extracts from air particulate matter from the region of the greater La Plata area was undertaken. Effects covered the study of mutagenicity with the Ames test (Salmonella typhimurium TA100 and TA98 strains with metabolic activation by S9) and cytotoxicity using the Tetrahymena pyriformis test system (growth rate, cell volume, and cell respiration). Chemical analysis of organic extracts was done using gas chromatography. Results demonstrate the presence of polycyclic aromatic hydrocarbons (PAH) in the matrix, high mutagenicity, and cytotoxicity. A higher mutagenic activity detected with TA98 and TA100 strains is associated with an increment of total PAH and total five or six ring PAH content, respectively. Linked with it, a PAH dependent toxicity on Tetrahymena pyriformis has been observed. This cell system proved to be very sensitive. From the results obtained with the cell respiration assay with T. pyriformis it appears that uncoupling agents are present in the samples. The results of this study indicate that air particulate matter from the Rio de La Plata area contains significant genotoxic and cytotoxic activity probably due to the ...Continue Reading

References

May 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J Lewtas
May 1, 1983·Mutation Research·D M Maron, B N Ames
May 1, 1980·Bulletin of Environmental Contamination and Toxicology·G A LeBlanc
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Citations

Jun 15, 2005·Environmental Monitoring and Assessment·Brian KeaneSteven H Rogstad
Dec 2, 2004·Mutation Research·Larry D ClaxtonSarah H Warren
Jul 14, 2007·Environmental Research·Susana MartinDeborah Ruth Tasat
Mar 4, 2008·Environmental Research·Agustín OstachukDeborah R Tasat
Sep 28, 2013·Ecotoxicology and Environmental Safety·Leticia PelusoAlicia E Ronco
Jan 25, 2012·Ecotoxicology and Environmental Safety·Anabella GiustoLucrecia Ferrari
Sep 1, 2006·Environmental Toxicology·Andrea MüllerAlicia Ronco
May 10, 2005·Environmental and Molecular Mutagenesis·Theo M de KokJos C Kleinjans
Jun 15, 2011·Environmental Science & Technology·Franziska SchrammGerrit Schüürmann

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