Assessment of trabecular bone score (TBS) in overweight/obese men: effect of metabolic and anthropometric factors

Endocrine
Elisabetta RomagnoliAndrea Lenzi

Abstract

The "trabecular bone score" (TBS) indirectly explores bone quality, independently of bone mineral density (BMD). We investigated the effects of anthropometric and metabolic parameters on TBS in 87 overweight/obese men. We assessed BMD and TBS by DXA, and some parameters of glucose metabolism, sex-and calciotropic hormone levels. Regression models were adjusted for either age and BMI, or age and waist circumference, or age and waist/hip ratio, also considering BMI >35 (y/n) and metabolic syndrome (MS) (y/n). Correlations between TBS and parameters studied were higher when correcting for waist circumference, although not significant in subjects with BMI >35. The analysis of covariance showed that the same model always had a higher adjusted r-square index. BMD at lumbar spine and total hip, fasting glucose, bioavailable testosterone, and sex hormone-binding globulin are the only covariates having a significant effect (p < 0.05) on the variations of TBS. The presence of MS negatively affected only the association between TBS and BMD at total hip. We did not find any significant effect of BMI >35 on TBS values or significant interaction terms between each covariate and either BMI >35 or the presence of MS. Obesity negatively affecte...Continue Reading

References

Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Dec 4, 2009·Calcified Tissue International·M Carola ZillikensFernando Rivadeneira
Nov 16, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V BoussonUNKNOWN Scientific Committee of the Groupe de Recherche et d’Information sur les Ostéoporoses
May 12, 2012·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Stefano GonnelliRanuccio Nuti
Aug 31, 2012·The Journal of Clinical Endocrinology and Metabolism·Miriam A BredellaKaren K Miller
Jan 24, 2013·The Journal of Clinical Endocrinology and Metabolism·William D LeslieUNKNOWN Manitoba Bone Density Program
Feb 2, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Melissa O PremaorDaniel Prieto-Alhambra
Mar 5, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·William D LeslieUNKNOWN Manitoba Bone Density Program
Jan 21, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara C SilvaJohn P Bilezikian
Apr 25, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C SennK Lippuner
May 24, 2014·Endocrine·Fabio M UlivieriRenata Caudarella
Aug 26, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·V CarnevaleE D'Erasmo
Nov 5, 2014·The Journal of Clinical Endocrinology and Metabolism·Jung Hee KimChan Soo Shin
Jan 15, 2015·Calcified Tissue International·J TouvierE Lespessailles
Mar 17, 2015·Endocrine·Marlies BekaertJohannes B Ruige
Jul 22, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V V ZhukouskayaI Chiodini
Aug 19, 2015·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Barbara C SilvaWilliam D Leslie
Sep 18, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John T SchousboeUNKNOWN Osteoporotic Fractures in Men MrOS Study Research Group
Oct 18, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J H KimC S Shin

❮ Previous
Next ❯

Citations

Oct 21, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lisa LangsetmoUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Dec 31, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Georges El KhouryRawad El Hage
Jan 31, 2017·Endocrinology and Metabolism Clinics of North America·Barbara C Silva, William D Leslie
Jan 27, 2018·The Journal of Clinical Endocrinology and Metabolism·Yu-Kwang Donovan TayJohn P Bilezikian
May 3, 2019·European Journal of Endocrinology·Cristina Eller-VainicherIacopo Chiodini
Jun 13, 2019·Menopause : the Journal of the North American Menopause Society·Şerife Ş TorgutalpFeza Korkusuz
Oct 2, 2017·Calcified Tissue International·Kara L HollowayJulie A Pasco
Jul 22, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A K NordklintP Eiken
Mar 16, 2017·Endocrine·Federico PontiAlberto Bazzocchi
Aug 4, 2020·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Miguel Ángel GuagnelliPatricia Clark
Feb 16, 2021·Frontiers in Endocrinology·Barbara StachowskaMarek Bolanowski
Feb 26, 2020·Seminars in Arthritis and Rheumatism·Stefanie F PiniJosé L Hernández-Hernández
Feb 24, 2021·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Ramón CostaSantos Castañeda
Mar 18, 2021·Journal of Endocrinological Investigation·B É C A SousaA M Kakehasi
Mar 7, 2021·Clinical Transplantation·Matej RakusaMojca Jensterle
Jun 2, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Iacopo ChiodiniLuigi Gennari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.