Assessment of transcriptomal analysis of Varicella-Zoster-virus gene expression in patients with and without post-herpetic neuralgia.

Virus Genes
G H AshrafiPeter G E Kennedy

Abstract

Varicella-Zoster virus (VZV) is a human herpes virus that reactivates from a latent state in human trigeminal and dorsal root ganglia to cause herpes zoster (shingles) which is a painful vesicular dermatomal skin eruption. The major complication of herpes zoster is post-herpetic neuralgia (PHN) which is a serious condition occurring especially in individuals over 50 years. PHN is extremely painful, may be permanent, and is frequently very refractory to all treatment. The ability to identify those patients with herpes zoster who are likely to develop PHN would be highly beneficial as it would allow pre-emptive anti-viral therapy. We have assessed the potential of using long oligonucleotide VZV microarrays to determine whether MeWo cells infected with VZV isolates obtained from 13 patients with zoster who had subsequently developed PHN showed significant transcriptomal differences from MeWo cells infected with viruses isolated from ten zoster patients who had not developed PHN. We found that viral gene expression from sample to sample within a group (PHN patients or non-PHN patients) varied as much, or more, than the viral gene expression between those groups. Quantitative real-time polymerase chain reaction studies carried out o...Continue Reading

References

May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P G KennedyJ W Gow
Jun 15, 1999·Virology·P G KennedyJ W Gow
Mar 4, 2000·The New England Journal of Medicine·D H GildenR J Cohrs
Sep 28, 2005·The Journal of General Virology·Peter G E KennedyPeter Ghazal
Jun 9, 2007·BMJ : British Medical Journal·David W Wareham, Judith Breuer

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