Assessment of tricalcium phosphate/collagen (TCP/collagene)nanocomposite scaffold compared with hydroxyapatite (HA) on healing of segmental femur bone defect in rabbits

Artificial Cells, Nanomedicine, and Biotechnology
Mahmoud MohseniSaeed Hesaraki

Abstract

Bone regeneration is an important objective in clinical practice and has been used for different applications. The aim of this study was to evaluate the effectiveness of nanocomposite tricalcium phosphate (TCP)/collagen scaffolds combined with hydroxyapatite scaffold for bone healing in surgery of femoral defects in rabbits. In this study, 45 mature male New Zealand white rabbits between 6 and 8 months old and weighting between 3 and 3.5 kg were examined. Rabbits were divided into three groups. Surgical procedures were performed after intramuscular injection of Ketamine 10% (ketamine hydrochloride, 50 mg/kg) and Rompun 5% (xylazine, 5 mg/kg). Then an approximately 6 mm diameter-5 mm cylinder bone defect was created in the femur of one of the hind limbs. After inducing the surgical wound, all rabbits were coloured and randomly divided into three experimental groups of 15 animals each. Group 1 received pure medical nanocomposite TCP/collagen granules, group 2 received hydroxyapatite, and third group was a control group which received no treatment. Histopathological evaluation was performed on days 15, 30, and 45 after surgery. On days 15, 30, and 45 after surgery, the quantity and the velocity of stages of bone formation at the h...Continue Reading

References

Jul 1, 1997·Journal of Biomedical Materials Research·S L IshaugA G Mikos
Aug 26, 1998·Journal of Orthopaedic Trauma·S D CookD C Rueger
Jun 1, 2000·Medical & Biological Engineering & Computing·B Chevallay, D Herbage
Nov 19, 2003·Advanced Drug Delivery Reviews·K GelseT Aigner
Nov 4, 2004·Biomaterials·Marc Bohner, Gamal Baroud
Apr 9, 2005·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Angela Min-Hwei NgRuszymah Binti Haji Idrus
Feb 7, 2006·Biomaterials·Chunmei LiDavid L Kaplan
Apr 29, 2006·Radiologic Clinics of North America·Francesca D BeamanMark J Kransdorf
May 16, 2009·Acta Biomaterialia·C I R BoissardD Eglin
Aug 18, 2009·Seminars in Cell & Developmental Biology·Katarina WolfPeter Friedl
Aug 21, 2010·Journal of Materials Science. Materials in Medicine·Shashwat BhaktaPaul V Hatton
Aug 26, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nguyen Thuy Ba LinhByong-Taek Lee
Apr 29, 2014·Journal of Biomedical Materials Research. Part a·Shen LiuCunyi Fan
Jul 7, 2015·International Journal of Biological Macromolecules·Mohammad ZuberNeelam Sultan

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Citations

May 16, 2018·Molecular Biotechnology·Nadeem SiddiquiSreenivasa Rao
Jul 2, 2019·International Journal of Molecular Medicine·Xiaoyan YuanJie Long
Nov 12, 2020·Military Medical Research·Shuai WeiXin-Long Ma
Oct 23, 2020·Journal of Biomedical Materials Research. Part a·Chunxiu MengFuzhai Cui

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