Assessment of troponin-T for detection of clinical cardiac rejection

Transplant International : Official Journal of the European Society for Organ Transplantation
B H WalpothB Reitz

Abstract

Non-invasive detection of cardiac rejection still remains a challenge after heart transplantation. We assessed troponin-T as a new serum marker to diagnose cardiac rejection. Twenty-five heart transplant patients (Berne) were monitored prospectively for up to 2 years, and compared to 89 retrospectively assessed patients (Stanford). Blood samples (392 Berne and 320 Stanford) were analyzed (creatine kinase, isoenzymes MB activity and MB mass, troponin-T and troponin-I). Regression analysis between the results of these blood samples and cardiac rejection grading from simultaneously performed endomyocardial biopsies was carried out. Troponin-T tests done in two different laboratories showed a good correlation (r = 0.91; P < 0.0001), whereas troponin-T versus troponin-I showed a lower correlation (r = 0.53; P < 0.0001). Troponin-T and -I in contrast to other enzymes were elevated for a longer period (up to 4 weeks before returning to baseline) after transplantation than during conventional cardiac surgery. Beyond 3 months the following correlations were found between troponin-T (new or old test) and the other enzymes (creatine kinase: r = 0.26, MB activity: r = 0.4, and MB mass: r = 0.68). The correlation between the degree of rejec...Continue Reading

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Citations

Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Tsuneo OgawaAdolfo J de Bold
Oct 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J ChanceD W Chan
Jun 5, 2007·Heart Failure Clinics·Thomas J DenglerHugo A Katus
Feb 13, 2003·Pediatric Transplantation·J SiaplaourasD Schranz
Jan 24, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Elisenda Bañón-ManeusPablo Pérez de la Ossa
Sep 3, 2013·Current Opinion in Organ Transplantation·Douglas A HillJames A de Lemos

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