Assessment of tumor promoting effects of amniotic and umbilical cord mesenchymal stem cells in vitro and in vivo

Journal of Cancer Research and Clinical Oncology
Ming-Yao MengZong-Liu Hou

Abstract

Human mesenchymal stem cells (hMSCs) have been applied in a variety of therapies recently. However, the role of MSCs in tumor progression remains largely elusive. Some studies demonstrated that MSCs can promote tumor growth, while others had opposite results. Therefore, the lack of evidence about the effect of MSCs on tumor cells impedes its further use. In the current study, hMSCs from amniotic membrane (hAMSCs) and umbilical cord (hUCMSCs) were used to evaluate the effects of MSCs on tumor development in vitro and in vivo. Two different animal models based on subcutaneous xenograft bearing nude mice and a murine experimental metastatic model were established for in vivo study. Moreover, cytokines regulated by MSCs co-cultured with cancer cells SPC-A-1 were also analyzed by cytokine array. Our results indicated that hUCMSCs not only did not promote proliferation in cancer cells, but also inhibited migration. In addition, they inhibited tube formation in human umbilical vein endothelial cells (HUVECs). Although hAMSCs also showed inhibitory effects on cancer cell motility, the proliferation of cancer cells was indeed enhanced. The in vivo data revealed that hUCMSCs did not promote tumor progression in lung adenocarcinoma and ga...Continue Reading

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Citations

Jul 9, 2020·Frontiers in Cell and Developmental Biology·Andrea PapaitAntonietta Rosa Silini
May 6, 2020·World Journal of Gastrointestinal Oncology·Jian-Nan LiKai Zhang
Feb 14, 2021·Stem Cell Research & Therapy·Ameneh JafariHassan Niknejad
Nov 3, 2020·Frontiers in Endocrinology·Jin LiYang Xia
Nov 27, 2020·Frontiers in Bioengineering and Biotechnology·Taja Železnik RamutaMateja Erdani Kreft
May 29, 2021·Frontiers in Oncology·Yuyi LiXinliang Lu

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Methods Mentioned

BETA
flow cytometry
Antibody Array
xenograft
antibody
xenografts

Software Mentioned

GraphPad
CellQuest
GraphPad Prism
Image J

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