Assessment of tumor treatment response using active contrast encoding (ACE)-MRI: Comparison with conventional DCE-MRI.

PloS One
Jin ZhangSungheon Gene Kim

Abstract

To investigate the validity of contrast kinetic parameter estimates from Active Contrast Encoding (ACE)-MRI against those from conventional Dynamic Contrast-Enhanced (DCE)-MRI for evaluation of tumor treatment response in mouse tumor models. The ACE-MRI method that incorporates measurement of T1 and B1 into the enhancement curve washout region, was implemented on a 7T MRI scanner to measure tracer kinetic model parameters of 4T1 and GL261 tumors with treatment using bevacizumab and 5FU. A portion of the same ACE-MRI data was used for conventional DCE-MRI data analysis with a separately measured pre-contrast T1 map. Tracer kinetic model parameters, such as Ktrans (permeability area surface product) and ve (extracellular space volume fraction), estimated from ACE-MRI were compared with those from DCE-MRI, in terms of correlation and Bland-Altman analyses. A three-fold increase of the median Ktrans by treatment was observed in the flank 4T1 tumors by both ACE-MRI and DCE-MRI. In contrast, the brain tumors did not show a significant change by the treatment in either ACE-MRI or DCE-MRI. Ktrans and ve values of the tumors from ACE-MRI were strongly correlated with those from DCE-MRI methods with correlation coefficients of 0.92 and 0...Continue Reading

References

Oct 24, 1998·Journal of Magnetic Resonance Imaging : JMRI·D A KovarG S Karczmar
Apr 30, 2003·Journal of Magnetic Resonance Imaging : JMRI·Peter L ChoykeMichael V Knopp
Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Stephen PickupHarold L Kundel
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher G WillettGregory Y Lauwers
Jan 11, 2007·British Journal of Cancer·J P B O'ConnorG C Jayson
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James J VredenburghHenry S Friedman
Dec 11, 2007·Magnetic Resonance Imaging·Sungheon KimHarish Poptani
Dec 28, 2007·The New England Journal of Medicine·Kathy MillerNancy E Davidson
Sep 17, 2008·International Journal of Radiation Oncology, Biology, Physics·Ashwatha NarayanaMichael L Gruber
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wei HuangCharles S Springer
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David W MilesGilles Romieu
Jan 8, 2013·Journal of Magnetic Resonance Imaging : JMRI·Kyunghyun SungBrian A Hargreaves
Oct 22, 2016·Journal of Magnetic Resonance Imaging : JMRI·Sungheon Gene KimLinda Moy
Sep 16, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Octavia BaneBachir Taouli
Feb 13, 2018·Nature Reviews. Clinical Oncology·Kabir A Khan, Robert S Kerbel

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