PMID: 7514953Jun 1, 1994Paper

Assessment of urinary beta-core fragment of human chorionic gonadotropin as a new tumor marker of lung cancer

Cancer
M YoshimuraN Tsubota

Abstract

Some patients with lung cancer have been found to have elevated levels of serum immunoreactive human chorionic gonadotropin (hCG)/hCG beta (IR-beta), but it is uncertain whether it would be valuable as a tumor marker. Recently, IR-beta has been demonstrated to consist of at least three different molecules, intact hCG, free hCG beta, and hCG beta-core fragment (beta-CF), in body fluids. In this study, the authors qualitatively analyzed IR-beta in the serum and urine of patients with lung cancer and assessed its clinical usefulness as a tumor marker. Highly sensitive and specific enzyme immunoassays were established to measure intact hCG, free hCG beta, and beta-CF in the serum and urine of patients with lung cancer. Of 99 patients with lung cancer, almost half of the patients achieved positive values of IR-beta in the urine, although only 12 had elevated values of IR-beta in the serum. The greater part of the elevated urinary IR-beta was identified to be beta-CF by gel chromatography on Sephadex G-100 (Pharmacia LKB Biotechnology, Tokyo, Japan), leading the authors to assess its usefulness as a tumor marker for lung cancer. Based on the cutoff value (0.2 ng/mg of creatinine) from healthy subjects, the overall positive rate of ur...Continue Reading

References

Mar 1, 1992·Journal of Surgical Oncology·R S D'AgostinoP E Schwartz
Sep 1, 1988·Molecular Endocrinology·L A Cole, S Birken
Sep 1, 1989·The Journal of Clinical Endocrinology and Metabolism·R E WehmannB C Nisula
Oct 1, 1989·Japanese Journal of Cancer Research : Gann·R NishimuraM Mochizuki
Jan 1, 1972·The Journal of Clinical Endocrinology and Metabolism·K J CattT Tsuruhara
Jan 1, 1973·Annals of Internal Medicine·G D BraunsteinG T Ross
Jun 1, 1968·The Journal of Clinical Endocrinology and Metabolism·K L BeckerS Katz
Oct 1, 1968·American Journal of Clinical Pathology·J C CottrellC F Moore

❮ Previous
Next ❯

Citations

Apr 16, 2013·Lancet·Abhishek GoyalDigambar Behera
Dec 20, 1996·Molecular and Cellular Endocrinology·S BirkenJ O'Connor
Oct 24, 2008·Human Reproduction Update·S F de Medeiros, R J Norman
Jul 6, 2004·Clinical Biochemistry·Ulf-Håkan StenmanKristina Hotakainen
Dec 2, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R NishimuraH Yasui
Mar 14, 2018·International Journal of Surgical Pathology·Elena MaryamchikAndrew E Rosenberg
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·T YokotaniR Nishimura
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G LiuA T Skarin
Apr 1, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R NishimuraH Yasui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
R NishimuraH Yasui
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
A SzilágyiW G Rossmanith
© 2021 Meta ULC. All rights reserved