Assessment of Valvular Disorders in Survivors of Hodgkin's Lymphoma Treated by Mediastinal Radiotherapy ± Chemotherapy

The American Journal of Cardiology
Jesse M BijlMarco C Post

Abstract

As the number of Hodgkin's lymphoma (HL) survivors grows, understanding long-term complications becomes more important. Mediastinal radiotherapy (MRT) seems to cause valvular disease, and the prevalence might increase during follow-up. In this cross-sectional study 82 HL survivors participated (52% men, mean age 47.8 years, 50 treated with MRT). Valvular disease was diagnosed by transthoracic echocardiography and compared between HL survivors treated with and without MRT. Univariate and multivariate logistic regression analysis was used to identify predictors for valvular disease. During a median follow-up of 13.4 years (range 2 to 39 years), ≥ mild valvular disease was present in 61.2% of HL survivors with MRT (n = 30), compared with 31.0% of HL survivors without MRT (n = 9; odds ratio [OR] 3.51, 95% CI 1.32 to 9.30, p = 0.01). In multivariate analysis, only current age remained predictive for ≥ mild valvular disease (OR 1.08 per year, 95% CI 1.01 to 1.14, p = 0.023). Aortic regurgitation (AR) was most prevalent and irradiated patients had significantly more ≥ mild AR (38.2% vs 6.8%, p = 0.007). Within the MRT subgroup, time after radiation of >15 years was associated with AR (OR 4.70, 95% CI 1.05 to 21.03, p = 0.043), after a...Continue Reading

References

Feb 1, 1997·The Thoracic and Cardiovascular Surgeon·G KleikampR Körfer
Dec 17, 2002·Critical Reviews in Oncology/hematology·M Jacob AdamsSteven E Lipshultz
Aug 23, 2003·Journal of the American College of Cardiology·Paul A HeidenreichIngela Schnittger
Dec 6, 2003·JAMA : the Journal of the American Medical Association·Matthew C HullNancy Price Mendenhall
Sep 19, 2006·Lancet·Vuyisile T NkomoMaurice Enriquez-Sarano
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jan 10, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Helmut BaumgartnerUNKNOWN European Association of Echocardiography
Feb 22, 2011·Cancer Treatment Reviews·Elena M van Leeuwen-SegarceanuDouwe H Biesma
Nov 16, 2012·Leukemia & Lymphoma·Elena M van Leeuwen-SegarceanuWillem-Jan W Bos

❮ Previous
Next ❯

Citations

May 27, 2017·Current Treatment Options in Cardiovascular Medicine·Merrill H StewartNichole M Polin
May 1, 2018·Current Treatment Options in Cardiovascular Medicine·Inbar Agmon Nardi, Zaza Iakobishvili
Aug 4, 2018·Heart Failure Reviews·Peggy M KostakouChristoforos D Olympios
Mar 8, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Marcelo F BenvenisteEdith M Marom
Jun 5, 2019·Current Treatment Options in Cardiovascular Medicine·Katherine Lee ChuyDipti Gupta
Mar 21, 2017·Current Atherosclerosis Reports·Deepa RaghunathanSyed Wamique Yusuf
Jun 21, 2018·Current Treatment Options in Cardiovascular Medicine·Michael C Honigberg, Amy A Sarma
Dec 29, 2020·Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï·S M KozhukhovN V Tkhor
Nov 14, 2019·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Ivica Ratosa, Maja Ivanetic Pantar
Jun 29, 2021·PM & R : the Journal of Injury, Function, and Rehabilitation·Nabela EnamMichael D Stubblefield
Sep 7, 2021·Journal of the American Heart Association·Eve Belzile-Dugas, Mark J Eisenberg
Aug 22, 2017·Indian Heart Journal·Arjun K Ghosh, J Malcolm Walker
Nov 7, 2020·Journal of the American College of Cardiology·Jose A Alvarez-CardonaUNKNOWN Cardio-Oncology Leadership Council

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