Assessment of vertebral microarchitecture in overt and mild Cushing's syndrome using trabecular bone score

Clinical Endocrinology
Helene VinolasAntoine Tabarin

Abstract

Osteoporotic fractures associated with Cushing's syndrome (CS) may occur despite normal bone mineral density (BMD). Few studies have described alterations in vertebral microarchitecture in glucocorticoid-treated patients and during CS. Trabecular bone score (TBS) estimates trabecular microarchitecture from dual-energy X-ray absorptiometry acquisitions. Our aim was to compare vertebral BMD and TBS in patients with overt CS and mild autonomous cortisol secretion (MACE), and following cure of overt CS. University Hospital. Monocentric retrospective cross-sectional and longitudinal studies of consecutive patients. A total of 110 patients were studied: 53 patients had CS (35, 11 and 7 patients with Cushing's disease, bilateral macronodular adrenal hyperplasia and ectopic ACTH secretion respectively); 39 patients had MACE (10 patients with a late post-operative recurrence of Cushing's disease and 29 patients with adrenal incidentalomas); 18 patients with non-secreting adrenal incidentalomas. 14 patients with overt CS were followed for up to 2 years after cure. Vertebral osteoporosis at BMD and degraded microarchitecture at TBS were found in 24% and 43% of patients with CS, respectively (P < .03). As compared to patients with nonsecre...Continue Reading

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Jul 3, 2018·Minerva endocrinologica·Giuseppe ReimondoMassimo Terzolo
Mar 14, 2019·The Journal of Clinical Endocrinology and Metabolism·Judith GerardsMarcus Quinkler
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Sep 30, 2021·Experimental and Therapeutic Medicine·Adina GhemigianAna Valea

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