Assessment of Vitamin D Level in Autoimmune Thyroiditis Patients and a Control Group in the Polish Population

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
Adam MaciejewskiKatarzyna Łącka

Abstract

Vitamin D, known for its role in calcium-phosphorus homeostasis, is also a significant immunomodulatory factor. Vitamin D deficiency has been reported in some autoimmune disorders. Recently, vitamin D level in autoimmune thyroiditis (HT - Hashimoto's thyroiditis) has become the subject of researchers' interest. This study aims to assess vitamin 25-OH-D3 levels in HT patients in comparison to a control group in the Polish population. This would be the first attempt conducted in this region with such poor sunlight exposure. The group we studied consisted of 62 subjects diagnosed with HT (mean age 49.15±15.51) and 32 healthy controls matched with age and sex (mean age 46.09±14.32). All blood samples were collected in the first quarter of the year to minimize the impact of seasonal fluctuations of vitamin D concentrations. In the HT group the mean vitamin D level was 20.09 nmol/L (SD±12.66), compared to 30.31 nmol/L (SD±19.49) in the controls, p=0.014. None of the patients and the controls was vitamin D sufficient (75-125 nmol/L). The deficiency (<50 nmol/L) was significantly more common among HT patients compared to the controls (61-98.4% vs. 27- 84.4%, p=0.029). In conclusion, we found that serum vitamin D concentration is signif...Continue Reading

Citations

Oct 14, 2014·Autoimmunity Reviews·Federica D'AurizioRenato Tozzoli
Jan 11, 2017·Reviews in Endocrine & Metabolic Disorders·Barbara AltieriSilvia Della Casa
Sep 17, 2020·Nutrients·Inês Henriques VieiraIsabel Paiva
Aug 25, 2021·BMC Endocrine Disorders·Sorour TaheriniyaGholamreza Askari

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