Assessment of wall stresses and mechanical heart power in the left ventricle: Finite element modeling versus Laplace analysis

International Journal for Numerical Methods in Biomedical Engineering
Matthias A F GsellGernot Plank

Abstract

Stenotic aortic valve disease (AS) causes pressure overload of the left ventricle (LV) that may trigger adverse remodeling and precipitate progression towards heart failure (HF). As myocardial energetics can be impaired during AS, LV wall stresses and biomechanical power provide a complementary view of LV performance that may aide in better assessing the state of disease. Using a high-resolution electro-mechanical (EM) in silico model of the LV as a reference, we evaluated clinically feasible Laplace-based methods for assessing global LV wall stresses and biomechanical power. We used N = 4 in silico finite element (FE) EM models of LV and aorta of patients suffering from AS. All models were personalized with clinical data under pretreatment conditions. Left ventricle wall stresses and biomechanical power were computed accurately from FE kinematic data and compared with Laplace-based estimation methods, which were applied to the same FE model data. Laplace estimates of LV wall stress are able to provide a rough approximation of global mean stress in the circumferential-longitudinal plane of the LV. However, according to FE results, spatial heterogeneity of stresses in the LV wall is significant, leading to major discrepancies be...Continue Reading

References

Jul 1, 1975·The Journal of Clinical Investigation·W GrossmanL P McLaurin
May 1, 1972·Journal of Biomechanics·H Demiray
Nov 1, 1971·Journal of Applied Physiology·N WesterhofP Sipkema
Oct 1, 1995·Journal of Biomechanics·J M GuccioneA D McCulloch
Jan 1, 1997·Annual Review of Physiology·J Sadoshima, S Izumo
Jan 13, 2004·Journal of Electrocardiology·Edward J VigmondL Joshua Leon
Feb 27, 2007·Journal of the American College of Cardiology·Hiroshi AshikagaJeffrey H Omens
Sep 29, 2007·Progress in Biophysics and Molecular Biology·E J VigmondG Plank
Apr 10, 2009·JACC. Cardiovascular Imaging·Hiroshi AshikagaJeffrey H Omens
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Gerhard A Holzapfel, Ray W Ogden
Aug 12, 2010·IEEE Transactions on Bio-medical Engineering·Bernardo M RochaGernot Plank
Oct 19, 2010·Cardiovascular Research·Steven A NiedererNicolas P Smith
Jul 30, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·El-Sayed H Ibrahim
Oct 5, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Steven A NiedererNic P Smith
Jun 1, 2012·Annals of Biomedical Engineering·J D BayerN A Trayanova
Jun 14, 2012·IEEE Transactions on Bio-medical Engineering·A NeicG Plank
Sep 4, 2013·The Journal of Clinical Investigation·William Grossman, Walter J Paulus
Jan 11, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yacine ElhmidiSabine Bleiziffer
Oct 2, 2015·Annals of Biomedical Engineering·A CrozierG Plank
Oct 12, 2015·International Journal of Cardiology·Peter AlterMarga B Rominger
Jan 26, 2016·Proceedings. Mathematical, Physical, and Engineering Sciences·Sander LandSteven A Niederer
Dec 25, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Christoph M AugustinGernot Plank
Jan 13, 2017·PloS One·Joao Filipe FernandesUNKNOWN CARDIOPROOF Consortium
Jan 18, 2017·Circulation. Cardiovascular Imaging·Fabrizio DonatiPablo Lamata
Feb 9, 2017·Journal of the American Heart Association·Nils Henrik Stubkjær HanssonHenrik Wiggers
Jan 26, 2018·European Journal of Heart Failure·Noman AliSteven J Lindsay

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Citations

May 17, 2019·Physics in Medicine and Biology·João PedrosaJan D'hooge
May 26, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Laura MarxGernot Plank
Dec 6, 2019·Biomechanics and Modeling in Mechanobiology·Christoph M AugustinSteven A Niederer
Oct 23, 2019·ACS Biomaterials Science & Engineering·Marita L RodriguezMarc N Hirt

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