Assessment of xerostomia and its impact on quality of life in head and neck cancer patients undergoing radiation therapy

Molecular and Clinical Oncology
Pinelopi-Theopisti MemtsaGeorge Kyrgias

Abstract

Xerostomia in head and neck (H&N) cancer patients significantly affects their quality of life (QoL). The aim of the present study was to investigate the associations among QoL, xerostomia and quantity of saliva in a sample of H&N cancer patients who had received conventional radiotherapy (RT). A total of 60 H&N adult patients were enrolled in this prospective study. The patients completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (QLQ-C30), the Quality of Life Questionnaire Head and Neck Module (QLQ-H&N35) and the Greek version of the XQ questionnaire at 4 timepoints: At the beginning of RT, at the end of RT, 6 months after RT completion and 1 year after RT completion. Patients with distant metastases or serious comorbidities were excluded from the study. Salivary pH, and stimulated and unstimulated salivary flow rate were assessed. All functional scales and symptom scales, apart from cognitive functioning in QLQ-C30 and feeding tube in H&N35 exhibited an abrupt deterioration at timepoint 3 and were then gradually restored over time. The difference was statistically significant (P<0.001). XQ scores at different timepoints exhibited a statistically significant negative c...Continue Reading

References

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Citations

Feb 7, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Wen-Jun FanLin Ma
Jul 29, 2020·Journal of Cancer Research and Therapeutics·Bhargavi IlangovanSubathira Balasundaram
Dec 7, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tharsana SelvakumarH M van Santen
May 23, 2021·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Melanie CharalambousAndreas Charalambous
Nov 6, 2021·Frontiers in Oncology·Sarah WepplerWendy Smith

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