Assessment using serum insulin-like growth factor-I and bone mineral density is useful for detecting prevalent vertebral fractures in patients with type 2 diabetes mellitus.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Ippei KanazawaT Sugimoto

Abstract

Bone mineral density (BMD) is less useful for evaluating fracture risk in type 2 diabetes. This study showed for the first time that combined evaluation by serum insulin-like growth factor-I and BMD is useful to assess the risk of vertebral fracture in postmenopausal women and men with type 2 diabetes. BMD is less useful for evaluating fracture risk in type 2 diabetes mellitus (T2DM). We aimed to examine the usefulness of combined evaluation by BMD and serum insulin-like growth factor-I (IGF-I) to assess the risk of vertebral fracture (VF) in T2DM. In this cross-sectional study, 412 postmenopausal women and 582 men with T2DM, whose BMD, bone turnover markers, and serum IGF-I were measured, were enrolled. The association of BMD alone, serum IGF-I alone, and combined assessment by BMD and IGF-I with the presence of VF was examined. Multiple logistic regression analyses showed that IGF-I as well as BMD T-score at lumbar (L) and femoral neck (FN) were significantly associated with VF except for IGF-I in men, respectively. Receiver operating characteristic curves showed that the cutoff values of IGF-I, L T-score and FN T-score were 127 ng/mL, - 1.78, and - 2.02 in postmenopausal women and 127 ng/mL, - 1.67, and - 1.24 in men. Based ...Continue Reading

References

Jun 27, 1992·Lancet·A G JohanssonS Ljunghall
Jan 1, 1989·Connective Tissue Research·T L McCarthyE Canalis
Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H K GenantS R Cummings
Jul 14, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R CenterJ A Eisman
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D BikleB Halloran
Nov 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Klara SjögrenClaes Ohlsson
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Fernando RivadeneiraAndre' G Uitterlinden
Nov 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Thor Ueland
Jun 14, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SaitoK Marumo
Oct 28, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Vestergaard
Nov 15, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J H MacdonaldC A Sharp
Jun 19, 2007·American Journal of Epidemiology·Mohsen JanghorbaniFrank B Hu
Jul 17, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I KanazawaT Sugimoto
Dec 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masahiro YamamotoToshitsugu Sugimoto
Dec 17, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Yoon K LokeCurt D Furberg
Jun 10, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I KanazawaT Sugimoto
Jun 3, 2011·JAMA : the Journal of the American Medical Association·Ann V SchwartzUNKNOWN Health, Aging, and Body Composition (Health ABC) Research Group
Sep 20, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Janina M PatschThomas M Link
May 26, 2016·American Journal of Physiology. Endocrinology and Metabolism·Johan SvenssonClaes Ohlsson
Oct 4, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Emily A Southmayd, Mary Jane De Souza

❮ Previous
Next ❯

Citations

Jun 21, 2019·Journal of Diabetes·Jian-Min LiuUNKNOWN Chinese Society of Osteoporosis and Bone Mineral Research, the Chinese Society of Endocrinology, Chinese Diabetes Society, C
Oct 7, 2019·The Journal of Clinical Endocrinology and Metabolism·Vicente F C AndradeCarolina Aguiar Moreira
Jan 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Shuai YuanSusanna C Larsson
Feb 2, 2021·Current Osteoporosis Reports·Julie Kristine KnudsenSuzette Sørensen
Jan 9, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F LvL Ji
Jan 8, 2021·Frontiers in Cell and Developmental Biology·Jing HouChangjun Li
Jan 16, 2021·Food & Nutrition Research·Rongrong LuZhuoqin Jiang
Sep 10, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Masayuki IchinoheYasuyuki Ishibashi
Mar 26, 2020·Current Diabetes Reviews·Moein AlaAhmad Reza Dehpour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Ippei KanazawaT Sugimoto
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Masahiro YamamotoToshitsugu Sugimoto
Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
Tamara J VokesMurray J Favus
© 2022 Meta ULC. All rights reserved