Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains

Neurobiology of Disease
Xin-Wen ZhouJin-Jing Pei

Abstract

Alzheimer's disease (AD) is characterized neuropathologically by neuritic plaques (NPs), and neurofibrillary tangles (NFTs). So far, the following key issues are not yet answered to the disease: (1) the accumulation degrees of three Abeta variants, and tau phosphorylation epitopes in AD as compared to control; (2) the correlation degrees of levels of three Abeta variants with different tau phosphorylation epitopes; (3) the correlation degrees of levels of three Abeta variants and different tau phosphorylation epitopes with Braak and CERAD staging systems. To address these issues, levels of Abeta40, Abeta42, and Abeta43, and phosphorylated tau were assessed by dot blots in homogenates of the medial temporal cortex from AD and control brains in the present study. These data implied different roles of tau phosphorylation epitopes in formation of NFTs, and in this process, Abeta might play a key role. Assessments of levels of these abnormal proteins by dot blots may serve as a useful complement to the morphological evaluations in diagnosis of AD.

References

Apr 1, 1991·Neuron·D J Selkoe
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N H SternbergerJ Ulrich
Jan 1, 1986·Journal of Neuropathology and Experimental Neurology·L C CorkD L Price
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G PerryP Gambetti
May 1, 1995·Neurobiology of Aging·D W DicksonP Davies
Jan 1, 1994·Annual Review of Neuroscience·D J Selkoe
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A TakashimaK Imahori
Jan 1, 1997·Journal of Neuropathology and Experimental Neurology·J J PeiI Grundke-Iqbal
Apr 1, 1997·Journal of Neurochemistry·C H ReynoldsB H Anderton
Jul 1, 1997·Journal of Neurochemistry·C H ReynoldsB H Anderton
Sep 28, 1999·Journal of Neuropathology and Experimental Neurology·J J PeiR F Cowburn
Mar 29, 2000·JAMA : the Journal of the American Medical Association·J NäslundJ D Buxbaum
Aug 22, 2000·Journal of Neuropathology and Experimental Neurology·D R ThalH Braak
Nov 18, 2000·Journal of Neuropathology and Experimental Neurology·X ZhuM A Smith
Jan 3, 2001·The Journal of Biological Chemistry·M S Wolfe, C Haass
Aug 23, 2002·The Journal of Biological Chemistry·Shinji SatoAkihiko Takashima
Nov 20, 2002·The Journal of Clinical Investigation·Dennis J Selkoe
Mar 8, 2003·Acta Neuropathologica·Jin-Jing PeiKhalid Iqbal
May 3, 2003·The American Journal of Psychiatry·Dorota ReligaVahram Haroutunian

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Citations

Jun 15, 2013·Cell Death & Disease·X-H LiX-W Zhou
Jul 9, 2009·Bioscience, Biotechnology, and Biochemistry·Hyo-Shin KimSo-Young Park
Jul 11, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Yan-Fang XianSiu-Po Ip
Jul 1, 2008·Neurobiology of Disease·Xin-Wen ZhouJin-Jing Pei
Jun 25, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·So-Young ParkDonggeun Sul
Feb 13, 2009·Journal of Cellular and Molecular Medicine·Jin-Jing Pei, Jacques Hugon
Jan 23, 2008·Journal of Cellular and Molecular Medicine·R LiuJ-J Pei
May 6, 2011·Journal of Neuroscience Research·Shan WangJin-Jing Pei
Jul 9, 2014·The EMBO Journal·Julia Banzhaf-StrathmannDieter Edbauer
Nov 23, 2019·The American Journal of Chinese Medicine·Hei-Jen HuangHsiu Mei Hsieh-Li
Sep 14, 2019·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Bin WangYanlin Bi
Jul 1, 2018·Acta Neuropathologica Communications·Joerg NeddensBirgit Hutter-Paier
Oct 16, 2018·Journal of Alzheimer's Disease : JAD·Lisa Müller-EhrenbergUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 11, 2012·Brain Pathology·Kristen M HenkinsKaren Hoppens Gylys
Dec 3, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·SpiroAnthony StathasThor D Stein

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