PMID: 8611376Mar 1, 1996Paper

Assesssment of the effect of pretreatment with neoadjuvant therapy on primary breast cancer

British Journal of Cancer
J C GazetR Sutcliffe

Abstract

Patients with invasive cancer of the breast (T1-4, N0-2, M0) were assigned to pretreatment based on oestrogen receptor (ER) status; patients with ER-negative tumours received chemotherapy [mitozantrone, methotrexate and mitomycin C (MMM)] for 3 months, patients with ER-positive tumours underwent endocrine therapy [luteinising hormone releasing hormone (LHRH) agonist goserelin (leuprolide-premenopausal) or 4-hydroxyandrostenedione (formestane-post-menopausal)] for 3 months. Of the first 100 patients assessed at 3 months, 47 with ER-positive tumours had a 40.4% response (premenopausal 53.8%; post-menopausal 35%) and 53 with ER-negative tumours had a 60% response (premenopausal 57%; post-menopausal 63%). Patients with early breast cancer (T1/T2) had a complete clinical resolution in 41% (16/39) of cases after MMM and in 20% (7/35) of cases following endocrine therapy compared with 14% (2/14) advanced tumours (T3/T4) following MMM and (0/12) following endocrine therapy. However, in those patients achieving a complete clinical response, subsequent appropriate surgery showed that 16 of 19 patients (84%) had evidence of residual viable tumour on histological examination.

Citations

Nov 5, 1997·American Journal of Clinical Oncology·H T ChangW S Tzeng
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I C SmithP F Sharp
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian C SmithKeith N Ogston
Jan 25, 2005·Breast Cancer Research and Treatment·Max ManoPeter Canney
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Selina RaguzErnesto Yagüe
Feb 18, 2004·The Breast : Official Journal of the European Society of Mastology·K L Cheung, J F Robertson
Sep 10, 2021·JAMA Oncology·Tal SellaOtto Metzger-Filho

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