PMID: 9546078Apr 18, 1998Paper

Assignment of three human markers in chromosome 21q11 to mouse chromosome 16

Somatic Cell and Molecular Genetics
J YuF T Kao

Abstract

Three unique sequence microclones from human chromosome region 21q11 were assigned to mouse chromosome 16 using a mouse/Chinese hamster cell hybrid 96Az2 containing a single mouse chromosome 16. This comparative mapping provides further homology between human chromosome 21 and mouse chromosome 16 to include the very proximal portion of the long arm of human chromosome 21. Since this part of human chromosome 21 is associated with mental retardation in Down syndrome individuals, its homologous mouse region should also be included in the construction of mouse models for studying Down syndrome phenotypes including mental retardation.

References

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F T Kao, J W Yu
Jul 1, 1980·The Journal of Experimental Medicine·C A Kozak, W P Rowe
Oct 1, 1995·Nature Genetics·R H ReevesM T Davisson
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·J R KorenbergC Disteche
Nov 1, 1995·Somatic Cell and Molecular Genetics·S L GrawD Patterson
May 1, 1996·Genomics·R W DeBry, M F Seldin
Dec 10, 1995·Genomics·G BrodskyF J Kaye
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·J YuF T Kao

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